PMA

PMA

Identifiers
IUPAC name 1-(4-methoxyphenyl)propan-2-amine
CAS Number	64-13-1
PubChem CID	31721
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H15NO
Molar mass	165.232 g/mol

WikiDoc Resources for PMA
Articles
Most recent articles on PMA Most cited articles on PMA Review articles on PMA Articles on PMA in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on PMA Images of PMA Photos of PMA Podcasts & MP3s on PMA Videos on PMA
Evidence Based Medicine
Cochrane Collaboration on PMA Bandolier on PMA TRIP on PMA
Clinical Trials
Ongoing Trials on PMA at Clinical Trials.gov Trial results on PMA Clinical Trials on PMA at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on PMA NICE Guidance on PMA NHS PRODIGY Guidance FDA on PMA CDC on PMA
Books
Books on PMA
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PMA in the news Be alerted to news on PMA News trends on PMA
Commentary
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Definitions
Definitions of PMA
Patient Resources / Community
Patient resources on PMA Discussion groups on PMA Patient Handouts on PMA Directions to Hospitals Treating PMA Risk calculators and risk factors for PMA
Healthcare Provider Resources
Symptoms of PMA Causes & Risk Factors for PMA Diagnostic studies for PMA Treatment of PMA
Continuing Medical Education (CME)
CME Programs on PMA
International
PMA en Espanol PMA en Francais
Business
PMA in the Marketplace Patents on PMA
Experimental / Informatics
List of terms related to PMA

8 pills of PMA recovered by the DEA

PMA 3D structure

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

PMA (paramethoxyamphetamine, p-methoxyamphetamine or 4-methoxyamphetamine) is a synthetic phenethylamine drug, psychostimulant and hallucinogen. It is commonly sold as "Ecstasy" and both dealers and users are likely to be unaware that a particular batch of pills contains PMA rather than MDMA. Notable batches of pills containing PMA have included Mitsubishi Turbo or Red/Blue Mitsubishi and Yellow Euro pills. PMA is often synthesized from anethole, the flavor compound of anise and fennel, mainly because the starting material for MDMA, safrole has become less available due to law enforcement action, causing illicit drug manufacturers to use anethole as an alternative. Once thought to be a human invention [3], recent research suggests PMA occurs as a trace alkaloid in plants including certain Acacia species. . It is classified as a Schedule I hallucinogen under the Controlled Substances Act in the United States. Internationally, PMA is a Schedule I drug under the Convention on Psychotropic Substances [4].

PMA has been associated with numerous adverse reactions including death. Effects of PMA ingestion include many effects of the hallucinogenic amphetamines including accelerated and irregular heartbeat, blurred vision, and a strong feeling of intoxication which is often unpleasant. While PMA can reportedly be euphoric at low doses, the dose-response curve is much steeper than that of MDMA, and at higher doses unpleasant effects such as nausea and vomiting, severe hyperthermia and hallucinations quickly overpower any pleasurable effects. The effects of PMA also seem to be much more unpredictable and variable between individuals than those of MDMA, and sensitive individuals may die from a dose of PMA that a less susceptible person might only be mildly affected by. There are approximately twice as many deaths caused by PMA as by MDMA, even though the actual proportion of PMA on the market is only a fraction of that of MDMA. While PMA alone may cause significant toxicity, the combination of PMA with MDMA has a synergistic effect which seems to be particularly hazardous. Since PMA has a slow onset of effects, several deaths have occurred where individuals have taken a pill containing PMA, followed by a pill containing MDMA some time afterwards due to thinking that the first pill was not active.

It appears that PMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit monoamine oxidase A and at the same time releasing large amounts of serotonin, effectively causing serotonin syndrome [5]. Amphetamines, especially serotonergic analogues such as MDMA, are strongly contraindicated to take with MAOIs. Many amphetamines and adrenergic compounds raise body temperatures; whereas some tend to produce more euphoric activity, or peripheral vasoconstriction, or tend to favor one effect over another, it appears that PMA activates the hypothalamus much more strongly than MDMA and other drugs like ephedrine, thereby causing rapid increases in body temperature (which is the major cause of death in PMA mortalities). Many people taking PMA try to get rid of the heat by taking off their clothes, taking cold showers or wrapping themselves in wet towels, and even sometimes by shaving off their hair.

Because PMA is given out through the same venues and distribution channels that "Ecstasy" tablets are, the risk of being severely injured, hospitalized or even killed from use of Ecstasy increases significantly when a batch of "Ecstasy" pills containing PMA starts to be sold in a particular area. PMA pills could be a variety of colours or logos, and there is no way of knowing just from the appearance of a pill what drugs it might contain. [6][7]. Due to the variations in street "Ecstasy" pills, the only way to reduce the risk of ingestion of PMA is to test any "Ecstasy" pill that is bought with a pill testing kit before it is consumed, and to monitor reported results from police or government drug testing laboratories and avoid any pills that are reported to contain PMA.

Four analogues of PMA have been reported to be sold on the black market: PMMA, PMEA , 4-ETA and 4-MTA. These are the N-methyl, N-ethyl, 4-ethoxy and 4-methylthio analogues of PMA, respectively. PMMA and PMEA are reportedly weaker, more "ecstasy-like" and somewhat less dangerous than PMA itself, but can still produce nausea and hyperthermia similar to that produced by PMA, albeit at slightly higher doses. 4-ETA was briefly sold in Canada in the 1970s but little is known about it. 4-MTA however is more dangerous even than PMA and produces strong stimulant effects and intense hyperthermia, but with little euphoria, and was implicated in several deaths in the late 1990s.

External links

• PIHKAL PMA entry
• The Hallucinogen PMA: Dancing With Death (in PDF format) from the Drug Enforcement Administration
• Death drug may become health crisis, news.ninemsn.com.au article, Issued 22 February 2007.

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