Sulbutiamine

	WikiDoc Resources for Sulbutiamine
Articles
Most recent articles on Sulbutiamine Most cited articles on Sulbutiamine Review articles on Sulbutiamine Articles on Sulbutiamine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Sulbutiamine Images of Sulbutiamine Photos of Sulbutiamine Podcasts & MP3s on Sulbutiamine Videos on Sulbutiamine
Evidence Based Medicine
Cochrane Collaboration on Sulbutiamine Bandolier on Sulbutiamine TRIP on Sulbutiamine
Clinical Trials
Ongoing Trials on Sulbutiamine at Clinical Trials.gov Trial results on Sulbutiamine Clinical Trials on Sulbutiamine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Sulbutiamine NICE Guidance on Sulbutiamine NHS PRODIGY Guidance FDA on Sulbutiamine CDC on Sulbutiamine
Books
Books on Sulbutiamine
News
Sulbutiamine in the news Be alerted to news on Sulbutiamine News trends on Sulbutiamine
Commentary
Blogs on Sulbutiamine
Definitions
Definitions of Sulbutiamine
Patient Resources / Community
Patient resources on Sulbutiamine Discussion groups on Sulbutiamine Patient Handouts on Sulbutiamine Directions to Hospitals Treating Sulbutiamine Risk calculators and risk factors for Sulbutiamine
Healthcare Provider Resources
Symptoms of Sulbutiamine Causes & Risk Factors for Sulbutiamine Diagnostic studies for Sulbutiamine Treatment of Sulbutiamine
Continuing Medical Education (CME)
CME Programs on Sulbutiamine
International
Sulbutiamine en Espanol Sulbutiamine en Francais
Business
Sulbutiamine in the Marketplace Patents on Sulbutiamine
Experimental / Informatics
List of terms related to Sulbutiamine

Sulbutiamine
Clinical data
Synonyms	Arcalion, bisibuthiamine, youvitan
Routes of; administration	Oral
ATC code	A11DA02 (WHO) ;
Pharmacokinetic data
Elimination half-life	5 hours
Excretion	Renal
Identifiers
	IUPAC name [4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl-; amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-; formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3-; yl]disulfanyl-pent-3-enyl] 2-methylpropanoate;
CAS Number	3286-46-2;
PubChem CID	71124;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C32H46N8O6S2
Molar mass	702.89 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC1=NC=C(C(=N1)N)CN(C=O)C(=C; (CCOC(=O)C(C)C)SSC(=C(C)N(CC2=; CN=C(N=C2N)C)C=O)CCOC(=O)C(C)C)C;

Overview

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B₁). It is indicated for the treatment of asthenia.^[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats^[2] and patients of schizophrenia^[2] suggests that it is a nootropic.

Effects

Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.^[3]

Dosage

Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,^[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.

References

↑ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia". J Assoc Physicians India. 51: 891&ndash, 5. PMID 14710977.
↑ ^2.0 ^2.1 ^2.2 Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task". Prog Neuropsychopharmacol Biol Psychiatry. 29 (6): 928&ndash, 35. PMID 15951087.
↑ http://www.serdiapharma.com/about/arcalion.asp

External links

"New Drugs that Make you Smart" by John Morgenthaler

Template:WH

Template:WS

[Shah-1] Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia". J Assoc Physicians India. 51: 891&ndash, 5. PMID 14710977.

[Bizot-2] 2.0 ^2.1 ^2.2 Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task". Prog Neuropsychopharmacol Biol Psychiatry. 29 (6): 928&ndash, 35. PMID 15951087.

[Serdia-3] ttp://www.serdiapharma.com/about/arcalion.asp

[1]

[2]

[3]