Atrial septal defect Eisenmenger's syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

The outcome among ASD patients with Eisenmenger's syndrome is generally poor irrespective of surgical or medical treatment.

Eisenmenger's Syndrome

If Eisenmenger's syndrome has developed, there is a significant risk of mortality regardless of the method of closure of the atrial septal defect. In individuals who have developed Eisenmenger's syndrome, the pressure in the right atrium is sufficiently elevated to reverse the shunt, and cause right to left shunting. If the atrial septal defect is then closed, the afterload that the right ventricle has to contract against suddenly increases and this may lead to acute right ventricular failure. Complications that occur as a result of Eisenmenger's syndrome include thrombosis and bleeding. Patients with Eisenmenger's syndrome should not become pregnant as there is an extremely high risk of maternal mortality.