CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]
Notable alleles
The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[4]
References
↑Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID2722762.
↑Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID10898111.
