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This 1966 photograph depicted a Brazilian mother, and her child who both manifested the dermal lesions determined to be due to the DNA virus, variola minor, otherwise known as “alastrim”. The mother had previously received a smallpox vaccination, resulting in what was a “negative take”, and exhibited a very minor form of alastrim, while her child was convalescing from the more classical form of the disease. Rarely, in some first-time, or distantly vaccinated (re-vaccinee) individuals, seemingly appropriate vaccination techniques may result in no reaction, otherwise known as a negative-take.