IL21R
(Redirected from IL21R gene)
| Interleukin 21 receptor | |||||||||||
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| Symbols | IL21R ; MGC10967; NILR | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 11040 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Interleukin 21 receptor, also known as IL21R, is a human gene.[1]
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.[1]
References
Further reading
- Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Ozaki K, Kikly K, Michalovich D; et al. (2000). "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11439–44. doi:10.1073/pnas.200360997. PMID 11016959.
- Parrish-Novak J, Dillon SR, Nelson A; et al. (2000). "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function". Nature. 408 (6808): 57–63. doi:10.1038/35040504. PMID 11081504.
- Asao H, Okuyama C, Kumaki S; et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. PMID 11418623.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Jüngel A, Distler JH, Kurowska-Stolarska M; et al. (2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis". Arthritis Rheum. 50 (5): 1468–76. doi:10.1002/art.20218. PMID 15146416.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Distler JH, Jüngel A, Kowal-Bielecka O; et al. (2005). "Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis". Arthritis Rheum. 52 (3): 856–64. doi:10.1002/art.20883. PMID 15751077.
- Wu Z, Kim HP, Xue HH; et al. (2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity". Mol. Cell. Biol. 25 (22): 9741–52. doi:10.1128/MCB.25.22.9741-9752.2005. PMID 16260592.
- de Totero D, Meazza R, Zupo S; et al. (2006). "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells". Blood. 107 (9): 3708–15. doi:10.1182/blood-2005-09-3535. PMID 16391014.
- Pène J, Guglielmi L, Gauchat JF; et al. (2007). "IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene". J. Immunol. 177 (8): 5006–13. PMID 17015683.
- Li J, Shen W, Kong K, Liu Z (2006). "Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis". Scand. J. Immunol. 64 (5): 515–22. doi:10.1111/j.1365-3083.2006.01795.x. PMID 17032244.
- Asano K, Ikegami H, Fujisawa T; et al. (2007). "Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes". Hum. Immunol. 68 (5): 384–91. doi:10.1016/j.humimm.2007.01.009. PMID 17462506.
- Akamatsu N, Yamada Y, Hasegawa H; et al. (2007). "High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma". Cancer Lett. 256 (2): 196–206. doi:10.1016/j.canlet.2007.06.001. PMID 17624663.
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