Leg pain

Leg pain Microchapters
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Causes of Leg pain
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

Leg pain is a common non-specific symptom that often has a musculoskeletal, metabolic or drug side effect basis.

Causes

Common Causes

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

Causes by Organ System

Cardiovascular	Aortoiliac occlusive disease, Cholesterol Emboli Syndrome, Deep Vein Thrombosis, Peripheral Arterial Disease, Thrombophlebitis, Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	Behcet's disease
Drug Side Effect	Abatacept Injection, Acebutolol, Acitretin, Aldesleukin, Alendronate, Allopurinol, Amikacin Sulfate Injection, Anagrelide, Anastrozole, Aripiprazole, Atazanavir, Atenolol, Atorvastatin, Bevacizumab Injection, Bortezomib, Buspirone, Capecitabine, Celecoxib, Celiac disease, Clofarabine Injection, Clonazepam, Clopidogrel, Cortisol, Darbepoetin Alfa, Docetaxel, Epoetin Alfa Injection, Ethacrynic Acid, Etidronate, Ezetimibe, Fenofibrate, Filgrastim, Fluvastatin, Gabapentin, Galantamine, Glatiramer Injection, Ibandronate, Iloprost, Imatinib, Infliximab Injection, Interferon Alfa-2a and Alfa-2b Injection, Interferon Alfacon-1 Injection, Interferon beta-1a Intramuscular Injection, Interferon Beta-1b Injection, Interferon Gamma-1b Injection, Lamivudine, Latanoprost, Leflunomide, Letrozole, Leuprolide, Lovastatin, Methimazole, Methylergonovine, Methylprednisolone, Mifepristone, Natalizumab injection , Ofloxacin , Paclitaxel, Peginterferon alfa-2a, Prednisone, Pyrazinamide, Quinupristin dalfopristin, Ribavirin, Rofecoxib, Rosiglitazone, Rosuvastatin, Sunitinib , Tadalafil , Tamsulosin , Telbivudine , Temozolomide , Terbutaline, Teriparatide, Tiotropium, Torsemide, Valganciclovir, Valsartan, Vancomycin, Vinblastine, Vincristine, Zalcitabine, Ziprasidone, Zolmitriptan, Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism, Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Ulcerative colitis
Genetic	Fairbanks disease, Familial Mediterranean fever, Mitochondrial trifunctional protein deficiency, Osteogenesis imperfecta, Hereditary multiple exostoses, Recessive multiple epiphyseal dysplasia, Farber disease
Hematologic	Erdheim-Chester disease, Leukemia, Lymphangiomatosis, Multiple myeloma, Phlebitis, Phlegmasia cerulea dolens, Thrombocytosis, Acute lymphoblastic leukemia, Acute myeloid leukemia, Acute promyelocytic leukemia, Cholesterol Embolism
Iatrogenic	No underlying causes
Infectious Disease	Bacterial : Cellulitis, Q Fever, Lassa Fever, Lemierre's Syndrome, Leptospirosis Viral : Parvovirus B19, Poliomyelitis, Rocky Mountain spotted fever, Acquired Immune Deficiency Syndrome, Coxsackie B,
Musculoskeletal / Ortho	Athlete's foot, Baker's cyst, Bone tumor, Buerger's disease, Chondroblastoma, Chondromalacia patellae, Chondrosarcoma, Gout, Hereditary multiple exostoses, Ledderhose's disease, Legg-Calve-Perthes syndrome, Morton's toe, Myofascial Pain Syndrome, Myositis ossificans, Osteochondrosis, Paget's disease of bone, Pes anserinus, Pigmented villonodular synovitis, Prepatellar bursitis, Recessive multiple epiphyseal dysplasia, Retropatellar Pain Syndrome, Sciatica, Synovial osteochondromatosis, Tenosynovitis, Erythromelagia, Ewing's sarcoma, Giant cell tumor of bone, Osteoporosis, Still's disease, Fairbanks disease, Osteogenesis imperfecta
Neurologic	Amyotrophic Lateral Sclerosis, Anterior spinal artery syndrome, Erythromelagia, Meralgia paraesthetica, Peripheral Neuropathy, Restless Leg Syndrome
Nutritional / Metabolic	Acute Intermittent Porphyria, Farber disease, Glycogen storage disease type V, Hypercalcemia, Mucopolysaccharidosis, Osteomalacia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia, Acute myeloid leukemia, Acute promyelocytic leukemia, Ewing's sarcoma, Giant cell tumor of bone, Osteochondroma, Osteoma, Osteosarcoma, Leukemia, Lymphangiomatosis, Chondroblastoma, Chondrosarcoma
Opthalmologic	Behect's disease
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia, Hypocalcemia, Hypokalemia, Hyponatremia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis, Behcet's disease, Caplan's Syndrome, Fibromyalgia, Osteoarthritis, Osteoporosis, Polymyalgia Rheumatica, Rheumatoid arthritis, Still's disease, Gout Immunology : Systemic lupus erythematosus, Ulcerative colitis, Vasculitis, Graft-versus-host disease, Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

Causes in Alphabetical Order

Abatacept Injection Acebutolol Acitretin Acquired Immune Deficiency Syndrome Acute Intermittent Porphyria Acute lymphoblastic leukemia Acute myeloid leukemia Acute promyelocytic leukemia Aldesleukin Alendronate Allopurinol Amikacin Sulfate Injection Amyotrophic Lateral Sclerosis Anagrelide Anastrozole Ankylosing Spondylitis Anterior spinal artery syndrome Aortoiliac occlusive disease Aripiprazole Atazanavir Atenolol Athlete's foot Atorvastatin Baker's cyst Behcet's disease Bevacizumab Injection Bone tumor Bortezomib Buerger's disease Buspirone Capecitabine Caplan's Syndrome Celecoxib Celiac disease Cellulitis Cholesterol Emboli Syndrome Chondroblastoma Chondromalacia patellae Chondrosarcoma Clofarabine Injection Clonazepam Clopidogrel Cortisol Coxsackie B Darbepoetin Alfa Injection Deep Vein Thrombosis Docetaxel Epoetin Alfa Injection Erdheim-Chester disease Erythromelagia Ethacrynic Acid Etidronate Ewing's sarcoma Ezetimibe Fairbanks disease Familial Mediterranean fever Farber disease Fenofibrate

Fibromyalgia Filgrastim Fluvastatin Gabapentin Galantamine Giant cell tumor of bone Glatiramer Injection Glycogen storage disease type V Gout Graft-versus-host disease Hereditary multiple exostoses Hypercalcemia Hypercalcemia Hyperparathyroidism Hypocalcemia Hypokalemia Hyponatremia Ibandronate Iloprost Imatinib Infliximab Injection Interferon Alfa-2a and Alfa-2b Injection Interferon Alfacon-1 Injection Interferon beta-1a Intramuscular Injection Interferon Beta-1b Injection Interferon Gamma-1b Injection Lamivudine Lassa Fever Latanoprost Ledderhose's disease Leflunomide Legg-Calve-Perthes syndrome Lemierre's Syndrome Letrozole Leukemia Leuprolide Lovastatin Lymphangiomatosis Meralgia paraesthetica Methimazole Methylergonovine Oral Methylprednisolone Oral Mifepristone Mitochondrial trifunctional protein deficiency Morton's toe Mucopolysaccharidosis Multiple myeloma Myofascial Pain Syndrome Myositis ossificans Natalizumab injection Ofloxacin Osteoarthritis Osteochondroma Osteochondrosis Osteogenesis imperfecta Osteoma Osteomalacia Osteoporosis

Osteosarcoma Paclitaxel Paget's disease of bone Pain disorder Parvovirus B19 Peg interferon alfa-2a Peripheral Arterial Disease Peripheral Neuropathy Pes anserinus(leg) Phantom pain Phlebitis Phlegmasia cerulea dolens Pigmented villonodular synovitis Poliomyelitis Polymyalgia Rheumatica Prednisone Prepatellar bursitis Primary hyperparathyroidism Pyrazinamide Q Fever Quinupristin and dalfopristin injection Recessive multiple epiphyseal dysplasia Retro patellar Pain Syndrome Rheumatoid arthritis Ribavirin Rocky Mountain spotted fever Rofecoxib Rosiglitazone Rosuvastatin Sciatica Still's disease Sunitinib Synovial osteochondromatosis Systemic lupus erythematosus Tadalafil Tamsulosin Telbivudine Temozolomide Tenosynovitis Terbutaline Teriparatide Thrombocytosis Thrombophlebitis Tiotropium Oral Inhalation Torsemide Injection Ulcerative colitis Valganciclovir Valsartan Vancomycin Varicose veins Vasculitis Vinblastine Vincristine Zalcitabine Ziprasidone Zolmitriptan Nasal Zolpidem

References

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