Meropenem Injection (patient information)

About your treatment

Your doctor has ordered meropenem, an antibiotic, to help treat your infection. The drug will be either injected into a large muscle (such as your buttock or hip) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 15 minutes or more, one to three times a day.

Meropenem eliminates bacteria that cause many kinds of infections, including pneumonia and urinary tract, skin, bone, and stomach infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how your infection and symptoms respond to the medication.

Precautions

Before administering meropenem:

• tell your doctor and pharmacist if you are allergic to meropenem, penicillin, cephalosporins [cefaclor (Ceclor), cefadroxil (Duricef), or cephalexin (Keflex)], or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially probenecid (Benemid), valproic acid (Depakene, Depakote), and vitamins.
• tell your doctor if you have or have ever had kidney or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking meropenem, call your doctor.

Administering your medication

Before you administer meropenem, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.

It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason because your infection could worsen and result in hospitalization. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.

Side effects

Minor side effects

Meropenem may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:

• upset stomach
• diarrhea
• stomach pain
• indigestion
• constipation
• dry mouth
• headache

Severe side effects

If you experience any of the following symptoms, call your health care provider immediately:

• seizures
• fatigue and sleepiness
• dizziness

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].

Storing your medication

Your health care provider may give you a several-day supply of meropenem at a time. You may receive vials and intravenous fluids to prepare your doses at home. You may receive a special bag with the vial of meropenem attached and directions on how to prepare the solution to infuse.

Store your medication only as directed. Make sure you understand what you need to store your medication properly.

Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Signs of infection

If you are receiving meropenem in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:

• tenderness
• warmth
• irritation
• drainage
• redness
• swelling
• pain

Brand names

• Merrem®