Myeloproliferative neoplasm laboratory findings

Myeloproliferative Neoplasm Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating myeloproliferative neoplasm from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Myeloproliferative neoplasm laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Myeloproliferative neoplasm laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Myeloproliferative neoplasm laboratory findings
on Myeloproliferative neoplasm laboratory findings
Myeloproliferative neoplasm laboratory findings in the news
Blogs on Myeloproliferative neoplasm laboratory findings
Directions to Hospitals Treating Myeloproliferative neoplasm
Risk calculators and risk factors for Myeloproliferative neoplasm laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

Laboratory findings associated with the diagnosis of myeloproliferative neoplasm include leukocytosis, thrombocytopenia, and anemia.

Laboratory Findings

Laboratory findings associated with myeloproliferative neoplasm include:

• Complete blood count

• Increased granulocytes of all types
• Increased basophils and eosinophils
• Thrombocytopenia or thrombocythemia
• Anemia or polycythemia

• Blood chemistry

• The following blood levels may be elevated:

• Blood urea nitrogen (BUN)
• Creatinine
• Phosphate
• Lactate dehydrogenase (LDH)
• Alanine aminotransferase (ALT)
• Aspartate transaminase (AST)
• Uric acid

• Bleeding and clotting factors

• The following blood parameters may be elevated:

• Prothrombin time (PT) or international normalized ratio (INR)
• Partial thromboplastin time (PTT)
• D-dimer

• Flow cytometry

• Flow cytometry helps determine the type of cells that are present.

• Cytogenetics or karyotyping

• Chromosome changes that may occur in some people with leukemia include:

• Translocations
• Inversions
• Loss or gain of a chromosome

• Fluorescent in situ hybridization (FISH)

• Similar to cytogenetics, but more specific for particular chromosomal translocations

• Polymerase chain reaction

• Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.

• Neutrophil alkaline phosphatase level
• Vitamin B12 (or B12 binding capacity) level
• Erythropoietin level
• Molecular testing for JAK2, CALR, and MPL mutations

Gallery

• 

  Representative Philadelphia negative metaphase bone marrow cell with a t(9;12)(q34;p13) translocation. (a) G-banded karyotype; (b) FISH analysis demonstrates lack of BCR-ABL1 fusion but reveals a small third signal from the ABL1 probe (arrow) and; (c) The ETV6 split signal (arrowed in red) on der(9)t(9;12) from the break-apart FISH probe shows the gene rearrangement and confirms G banding results. The red/green fusion signal marks the normal gene.