Surfactant protein D

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.

SFTPD is an innate immune system collectin.

Interactions

Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of influenza A virus.

See also

• pulmonary surfactant

External links

• Surfactant+Protein+D at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Hansen S, Holmskov U (1998). "Structural aspects of collectins and receptors for collectins". Immunobiology. 199 (2): 165–89. doi:10.1016/s0171-2985(98)80025-9. PMID 9777404.
• Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
• Persson AV, Gibbons BJ, Shoemaker JD, Moxley MA, Longmore WJ (1992). "The major glycolipid recognized by SP-D in surfactant is phosphatidylinositol". Biochemistry. 31 (48): 12183–9. PMID 1457414.
• Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
• Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
• Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochim. Biophys. Acta. 1086 (2): 185–90. doi:10.1016/0005-2760(91)90006-4. PMID 1932100.
• Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
• Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
• Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics. 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
• Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis". Am. J. Pathol. 142 (1): 241–8. PMC 1886847. PMID 8424457.
• Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
• Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. doi:10.1165/ajrcmb.14.2.8630261. PMID 8630261.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
• Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. doi:10.1073/pnas.95.20.11869. PMC 21732. PMID 9751757.
• Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D". Structure. 7 (3): 255–64. doi:10.1016/S0969-2126(99)80036-7. PMID 10368295.
• Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905.
• Lausen M, Lynch N, Schlosser A, Tornoe I, Saekmose SG, Teisner B, Willis AC, Crouch E, Schwaeble W, Holmskov U (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D". J. Biol. Chem. 274 (45): 32234–40. doi:10.1074/jbc.274.45.32234. PMID 10542261.
• Madsen J, Kliem A, Tornoe I, Skjodt K, Koch C, Holmskov U (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues". J. Immunol. 164 (11): 5866–70. doi:10.4049/jimmunol.164.11.5866. PMID 10820266.
• Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.