Diethylcathinone

Diethylcathinone

Clinical data
Pregnancy category	B
ATC code	A08AA03 (WHO)
Legal status
Legal status	US: Schedule IV
Identifiers
IUPAC name 2-diethylamino-1-phenyl-propan-1-one
CAS Number	90-84-6
PubChem CID	7029
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C13H19NO
Molar mass	241.76

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Overview

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.

Pharmacology

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl analog of cathinone and dimethylcathinone. Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate®, Tepanil Ten-Tab®). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contraindications

• Hypersensitivity to sympathomimetic amines
• Advanced arteriosclerosis or symptomatic cardiovascular disease
• Moderate or severe hypertension
• Hyperthyroidism
• History of drug abuse
• MAO inhibitor use (within 14 days)

Side effects

Severe

• Pulmonary hypertension
• Stroke
• Psychosis

Cardiovascular

• Tachycardia, hypertension, arrhythmia, chest pain

Ear, nose, and throat

• Xerostomia, metallic taste

Endocrine

• Changes in libido, gynecomastia, menstrual irregularities

Eye

• Blurred vision

Gastrointestinal

• Nausea/vomiting, constipation, abdominal cramps

Hematological

• Bone marrow depression, agranulocytosis, leukopenia

Neurological

• Tremor

Psychological

• Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

Skin

• Rash, hives, alopecia, ecchymosis

Urogenital and reproductive

• Changes in libido, impotence

See also

• Methcathinone
• Methylenedioxymethcathinone

References

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