Serum iron

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The medical laboratory test for serum iron measures the amount of circulating iron that is bound to transferrin.

Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems.

65% of the iron in the body is bound up in hemoglobin molecules in red blood cells. About 4% is bound up in myoglobin molecules. Around 30% of the iron in the body is stored as ferritin or hemosiderin in the spleen, the bone marrow and the liver. Small amounts of iron can be found in other molecules in cells throughout the body. None of this iron is directly accessible by testing the serum.

However, some iron is circulating in the serum. Transferrin is a molecule produced by the liver that binds one or two iron(III) ions; transferrin is essential if stored iron is to be moved and used.

Most of the time, about 30% of the available sites on the transferrin molecule are filled. The test for serum iron uses blood drawn from veins to measure the iron molecules that are bound to transferrin, and circulating in the blood.

The extent to which sites on transferrin molecules are filled by iron ions can be another helpful clinical indicator, known as percent transferrin saturation. Another lab test saturates the sample to measure the total amount of transferrin; this test is called total iron-binding capacity (TIBC). These three tests are generally done at the same time, and taken together are an important part of the diagnostic process for anemia, iron deficiency, iron deficiency anemia and Haemochromatosis.

Normal values

• Serum Iron (SI):
  • Men: 65 to 176 µg/dL
  • Women: 50 to 170 µg/dL
  • Newborns: 100 to 250 µg/dL
  • Children: 50 to 120 µg/dL
• TIBC: 240-450 µg/dL
• Transferrin saturation: 20-50%

µg/dL = micrograms per deciliter.

Laboratories often use different units and "normal" may vary by population and the lab techniques used; look at the individual laboratory reference values to interpret a specific test (for instance, your own).

References

• Medline Plus Medical Encyclopedia: Serum Iron.
• Schrier SL. Regulation of iron balance. Up-to-Date. Accessed December 5, 2005. (Requires subscription.)
• University of Illinois Medical Center: Serum Iron. Accessed July 6, 2006.

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