View source for Hyperostosis

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 | DiseasesDB     = 30719
 | ICD10          = {{ICD10|M|85|8|m|80}}
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 | MeshID         = D015576
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'''Hyperostosis''' is an excessive growth of [[bone]]. It may lead to [[exostosis]]. It occurs in many [[musculoskeletal disorders]].

It is the thickening of the cortical bone.

[[Hyperphosphatemia]]-hyperostosis syndrome (HHS) is a rare autosomal recessive metabolic disorder characterized by elevated serum phosphate levels and radiological evidence of cortical hyperostosis.<ref name=Frishberg>{{ cite journal |author=Frishberg Y, Topaz O, Bergman R, Behar D, Fisher D, Gordon D, Richard G, Sprecher E |title=Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders |journal=J Mol Med. |year=2005 |month=Jan |volume=83 |issue=1 |pages=33-8 |pmid=15599692 }}</ref> HHS is caused by mutations in GALNT3.<ref name=Ichikawa>{{ cite journal |author=Ichikawa S, Guigonis V, Imel EA, Courouble M, Heissat S, Henley JD, Sorenson AH, Petit B, Lienhardt A, Econs MJ |title=Novel GALNT3 mutations causing hyperostosis-hyperphosphatemia syndrome result in low intact fibroblast growth factor 23 concentrations |journal=J Clin Endocrinol Metab. |year=2007 |month=May |volume=92 |issue=5 |pages=1943-7 |pmid=17311862 }}</ref>

===Causes===

===Drug Side Effect===

* [[Isotretinoin]]

=References=
{{reflist|2}}

==See also==
* [[Infantile cortical hyperostosis]]


{{Osteochondropathy}}
	
[[Category:Gross pathology]]

[[it:Iperostosi]]



[[Category:Signs and symptoms]]
[[Category:Surgery]]

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