View source for Magnesium chloride

{{DrugProjectFormSinglePage
|authorTag={{Ammu}}
|genericName=magnesium chloride
|aOrAn=a
|drugClass=electrolyte
|indicationType=treatment
|indication=as an electrolyte replenisher in magnesium deficiencies
|adverseReactions=[[flushing]], [[sweating]], sharply lowered blood pressure, [[hypothermia]], [[stupor]], and ultimately respiratory depression.
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>

* Content

<!--Adult Indications and Dosage-->

<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=* As an electrolyte replenisher in magnesium deficiencies.
* For intravenous infusion: 4 grams in 250 mL of 5% Dextrose Injection, at a rate not exceeding 3 mL per minute. Serum magnesium levels should serve as a guide to continued dosage.
* USUAL DOSAGE RANGE: 1 to 40 grams daily.
* Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.

<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.

<!--Pediatric Indications and Dosage-->

<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed=There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.

<!--Off-Label Use and Dosage (Pediatric)-->

<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.

<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.

<!--Contraindications-->
|contraindications=* Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.
|warnings=* Do not use if a precipitate is present.
* This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
* Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
|postmarketing=* Flushing, [[sweating]], sharply lowered blood pressure, [[hypothermia]], [[stupor]], and ultimately respiratory depression.
|FDAPregCat=C
|useInPregnancyFDA=* Animal reproduction studies have not been conducted with magnesium chloride. It is also not known whether magnesium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium chloride should be given to a pregnant woman only if clearly needed.
|useInPregnancyAUS=There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.

<!--Administration and Monitoring-->
|administration=* Intravenous
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


<!--IV Compatibility-->
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.

<!--Overdosage-->
|drugBox={{chembox2
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 459589655
| ImageFile = Magnesium chloride.jpg
| ImageSize = 200px 
| ImageFile1 = Magnesium-chloride-3D-polyhedra.png
| IUPACName = Magnesium chloride
| SystematicName = Magnesium chloride
| OtherNames = Magnesium dichloride
| Section1 = {{Chembox Identifiers
| Abbreviations = 
| CASNo = 7786-30-3
| CASNo_Ref = {{cascite|correct|CAS}}
| CASOther = <br/>{{CAS|7791-18-6}} (hexahydrate) <!--also verified against the Chemical Abstracts Service list -->
| EINECS = 
| EINECSCASNO = 
| PubChem = 24584
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200547
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 22987
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6636
| SMILES = [Mg+2].[Cl-].[Cl-]
| InChI = InChI=1S/2ClH.Mg/h2*1H;/q;;+2/p-2
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/2ClH.Mg/h2*1H;/q;;+2/p-2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = TWRXJAOTZQYOKJ-UHFFFAOYSA-L 
| RTECS = OM2975000
| ATCCode_prefix = A12
| ATCCode_suffix = CC01
| ATC_Supplemental = {{ATC|B05|XA11}}
  }}
| Section2 = {{Chembox Properties
| Formula = MgCl<sub>2</sub>
| MolarMass = 95.211 g/mol (anhydrous)<br/>203.31 g/mol (hexahydrate)
| Appearance = white or colourless crystalline solid
| Density = 2.32 g/cm<sup>3</sup> (anhydrous) <br> 1.569 g/cm<sup>3</sup> (hexahydrate)
| MeltingPtC = 714
| Melting_notes = {{convert|117|C|F K}} (hexahydrate) <br> on rapid heating: slow heating leads to decomposition from {{convert|300|C|F K}}
| BoilingPtC = 1412
| Boiling_notes = 
| Solubility = ''anhydrous'' 52.9 g/100 mL (0 °C) <br> <br> 54.3 g/100 ml (20&nbsp;°C) <br> 72.6 g/100 mL (100&nbsp;°C) <hr> ''hexahydrate'' <br> 167 g/100 mL (20&nbsp;°C)
| Solubility1 = 7.4 g/100 mL (30&nbsp;°C)
| Solvent1 = ethanol
| SolubleOther = slightly soluble in [[acetone]], [[pyridine]]
| LogP = 
| HenryConstant = 
| RefractIndex = 1.675 (anhydrous) <br> 1.569 (hexahydrate)
  }}
| Section3 = {{Chembox Structure
| CrystalStruct = [[Cadmium chloride#Crystal structure|CdCl<sub>2</sub>]]
| Coordination = (octahedral, 6-coordinate)
| MolShape = 
  }}
| Section4 = {{Chembox Thermochemistry
| DeltaHf = -641.1 kJ/mol
| DeltaGf = -591.6 kJ/mol
| Entropy = 89.88 J/mol K
| HeatCapacity = 71.09 J/mol K
  }}
| Section7 = {{Chembox Hazards
| ExternalMSDS = [http://www.inchem.org/documents/icsc/icsc/eics0764.htm ICSC 0764]
| EUClass = 
| EUIndex = Not listed
| MainHazards = Irritant
| NFPA-H = 1
| NFPA-F = 0
| NFPA-R = 0
| NFPA-S = 
| RPhrases = {{R36}}, {{R37}}, {{R38}}
| SPhrases = {{S26}}, {{S37}}, {{S39}}
| FlashPt = Non-flammable
| LD50 = 2800 mg/kg (oral, rat)
| PEL = 
  }}
| Section8 = {{Chembox Related
| OtherAnions = [[Magnesium fluoride]]<br/>[[Magnesium bromide]]<br/>[[Magnesium iodide]]
| OtherCations = [[Beryllium chloride]]<br/>[[Calcium chloride]]<br/>[[Strontium chloride]]<br/>[[Barium chloride]]<br/>[[Radium chloride]]
| OtherFunctn = 
| Function = 
| OtherCpds = 
  }}
}}
|structure=* Magnesium Chloride Injection is a sterile solution of Magnesium Chloride Hexahydrate in Water for Injection q.s. Each mL contains: Magnesium Chloride Hexahydrate 200 mg, Sodium Chloride 9 mg, Benzyl Alcohol 1% as a preservative, * Water for Injection, q.s. pH adjusted with Hydrochloric Acid and/or Sodium Hydroxide. Total osmolarity equivalent to 2951 mOsmol/L. Contains 1.97 mEq of Mg++ and Cl¯ per mL.
The structural formula is MgCl2•6H2O
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.

<!--Pharmacokinetics-->
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.

<!--Nonclinical Toxicology-->
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.

<!--Clinical Studies-->
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.

<!--How Supplied-->
|howSupplied=* Magnesium Chloride Injection 200 mg/mL (20% w/v)
* NDC 0517-5034-01     50 mL Multiple Dose Vial     Individually boxed
|storage=* Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F)
|packLabel=<!--Patient Counseling Information-->
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.

<!--Precautions with Alcohol-->
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

<!--Brand Names-->
|brandNames=*MAGNESIUM CHLORIDE  ®<ref>{{Cite web | title =MAGNESIUM CHLORIDE - magnesium chloride injection, solution   | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c9f69e8d-bc97-4183-bad2-b0468f0a586a }}</ref>

<!--Look-Alike Drug Names-->
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>

<!--Drug Shortage Status-->
|drugShortage=
}}
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[[Category:Drug]]