View source for Androgen-binding protein

{{unreferenced|date=February 2015}}
{{infobox protein
| Name = Androgen-binding protein, Sex hormone-binding globulin
| caption = 
| image = 
| width = 
| HGNCid = 10839
| Symbol = SHBG
| AltSymbols = ABP
| EntrezGene = 6462
| OMIM = 182205
| RefSeq = NM_001040
| UniProt = P04278
| PDB = 
| ECnumber = 
| Chromosome = 17
| Arm = p
| Band = 13
| LocusSupplementaryData = -p12
}}

'''Androgen-binding protein''' ('''ABP''') is a [[glycoprotein]] (beta-[[globulin]]) produced by the [[Sertoli cells]] in the [[seminiferous tubules]] of the [[testis]] that binds specifically to [[testosterone]] (T), [[dihydrotestosterone]] (DHT), and 17-beta-[[estradiol]].

Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable [[spermatogenesis]] in the [[seminiferous tubules]] and sperm maturation in the [[epididymis]].

ABP has the same [[amino acid]] sequence as [[sex hormone-binding globulin]] ([[SHBG]]); the difference is the site of production and the addition of different sugar moieties. ABP contains 403 amino acids, resulting in a [[molecular weight]] of 44,533. Its gene is located on [[chromosome 17]].

ABP’s production is regulated under influence of [[Follicle-stimulating hormone|FSH]] on Sertoli cell, enhanced by [[insulin]], [[retinol]], and [[testosterone]].

ABP may also be secreted in other organs; for instance, mice produce a [[saliva]]ry ABP.

== See also ==
*[[Sex hormone-binding globulin]] (SHBG)

== References ==
* {{MeshName|Androgen-Binding+Protein}}

==External links==
* {{Ensembl|ENSG00000129214}}


{{Carrier proteins}}
{{Androgenics}}
{{Estrogenics}}

[[Category:Glycoproteins]]