View source for CIDEA

{{Underlinked|date=May 2016}}
{{Infobox_gene}}
'''Cell death activator CIDE-A''' is a [[protein]] that in humans is encoded by the ''CIDEA'' [[gene]].<ref name="pmid9564035">{{cite journal | vauthors = Inohara N, Koseki T, Chen S, Wu X, Nunez G | title = CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor | journal = EMBO J | volume = 17 | issue = 9 | pages = 2526–33 |date=Jun 1998 | pmid = 9564035 | pmc = 1170594 | doi = 10.1093/emboj/17.9.2526 }}</ref><ref name="pmid18509062">{{cite journal | vauthors = Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP | title = Cidea is associated with lipid droplets and insulin sensitivity in humans | journal = Proc Natl Acad Sci U S A | volume = 105 | issue = 22 | pages = 7833–8 |date=Jun 2008 | pmid = 18509062 | pmc = 2409392 | doi = 10.1073/pnas.0802063105 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CIDEA cell death-inducing DFFA-like effector a| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1149| accessdate = }}</ref> Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.<ref>[http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2614.html Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids]</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.<ref name="entrez" />
}}

==References==
{{reflist}}

==External links==
* {{UCSC gene info|CIDEA}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | vauthors=Zhang L, Miyaki K, Nakayama T, Muramatsu M |title=Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men |journal=Metab. Clin. Exp. |volume=57 |issue= 4 |pages= 502–5 |year=  2008|pmid= 18328351 |doi= 10.1016/j.metabol.2007.11.011 }}
*{{cite journal  | vauthors=Li D, Da L, Tang H |title=CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding |journal=Nucleic Acids Res. |volume=36 |issue= 1 |pages= 330–41 |year= 2008 |pmid= 18033804 |doi= 10.1093/nar/gkm1028  | pmc=2248752 |display-authors=etal}}
*{{cite journal  | vauthors=Gummesson A, Jernås M, Svensson PA |title=Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 12 |pages= 4759–65 |year= 2008 |pmid= 17895319 |doi= 10.1210/jc.2007-1136 |display-authors=etal}}
*{{cite journal  | vauthors=Iwahana H, Yakymovych I, Dubrovska A |title=Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis |journal=Proteomics |volume=6 |issue= 23 |pages= 6168–80 |year= 2007 |pmid= 17080483 |doi= 10.1002/pmic.200600384 |display-authors=etal}}
*{{cite journal  | vauthors=Dahlman I, Kaaman M, Jiao H |title=The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects |journal=Diabetes |volume=54 |issue= 10 |pages= 3032–4 |year= 2005 |pmid= 16186410 |doi=10.2337/diabetes.54.10.3032  |display-authors=etal}}
*{{cite journal  | vauthors=Nordström EA, Rydén M, Backlund EC |title=A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity |journal=Diabetes |volume=54 |issue= 6 |pages= 1726–34 |year= 2005 |pmid= 15919794 |doi=10.2337/diabetes.54.6.1726  |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Zhou Z, Yon Toh S, Chen Z |title=Cidea-deficient mice have lean phenotype and are resistant to obesity |journal=Nat. Genet. |volume=35 |issue= 1 |pages= 49–56 |year= 2003 |pmid= 12910269 |doi= 10.1038/ng1225 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Chen Z, Guo K, Toh SY |title=Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22619–22 |year= 2000 |pmid= 10837461 |doi= 10.1074/jbc.C000207200 |display-authors=etal}}
}}
{{refend}}

<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{gene-18-stub}}