View source for Cathepsin L2

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{{Infobox_gene}}
'''Cathepsin L2''', also known as '''cathepsin V''' and encoded by the '''CTSL2''' gene, is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CTSL2 cathepsin L2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1515| accessdate = }}</ref>

The protein encoded by this gene, a member of the [[peptidase]] [[C1 family]], is a lysosomal cysteine proteinase that may play an important role in [[cornea]]l physiology. This gene is expressed in colorectal and [[breast carcinoma]]s but not in normal [[Colon (anatomy)|colon]], mammary gland, or peritumoral tissues, suggesting a possible role for this gene in [[tumor]] processes.

==Clinical significance==
Cathepsin L2 may play a role in the pathogenesis of [[keratoconus]].<ref name="Kenney05">{{cite journal | vauthors = Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V, Adachi W, Brown DJ | year = 2005 | title = Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder | url = | journal = Invest. Ophthal. Vis. Sci. | volume = 46 | issue = | pages = 823–832 | doi = 10.1167/iovs.04-0549 | pmid = 15728537 }}</ref>

==References==
{{reflist}}

==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C01.009 C01.009]

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Santamaría I, Velasco G, Cazorla M |title=Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. |journal=Cancer Res. |volume=58 |issue= 8 |pages= 1624–30 |year= 1998 |pmid= 9563472 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=Adachi W, Kawamoto S, Ohno I |title=Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 10 |pages= 1789–96 |year= 1998 |pmid= 9727401 |doi=  |display-authors=etal}}
*{{cite journal  | vauthors=Brömme D, Li Z, Barnes M, Mehler E |title=Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. |journal=Biochemistry |volume=38 |issue= 8 |pages= 2377–85 |year= 1999 |pmid= 10029531 |doi= 10.1021/bi982175f }}
*{{cite journal  | vauthors=Itoh R, Kawamoto S, Adachi W |title=Genomic organization and chromosomal localization of the human cathepsin L2 gene. |journal=DNA Res. |volume=6 |issue= 2 |pages= 137–40 |year= 1999 |pmid= 10382972 |doi=10.1093/dnares/6.2.137  |display-authors=etal}}
*{{cite journal  | vauthors=Somoza JR, Zhan H, Bowman KK |title=Crystal structure of human cathepsin V. |journal=Biochemistry |volume=39 |issue= 41 |pages= 12543–51 |year= 2000 |pmid= 11027133 |doi=10.1021/bi000951p  |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
*{{cite journal  | vauthors=Bernard D, Méhul B, Thomas-Collignon A |title=Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2. |journal=J. Invest. Dermatol. |volume=120 |issue= 4 |pages= 592–600 |year= 2003 |pmid= 12648222 |doi= 10.1046/j.1523-1747.2003.12086.x |display-authors=etal}}
*{{cite journal  | vauthors=Tolosa E, Li W, Yasuda Y |title=Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. |journal=J. Clin. Invest. |volume=112 |issue= 4 |pages= 517–26 |year= 2003 |pmid= 12925692 |doi= 10.1172/JCI18028 |pmc=171390|display-authors=etal}}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697|display-authors=etal}}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 |pmc=2734081|display-authors=etal}}
*{{cite journal  | vauthors=Yasuda Y, Li Z, Greenbaum D |title=Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36761–70 |year= 2004 |pmid= 15192101 |doi= 10.1074/jbc.M403986200 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
*{{cite journal  | vauthors=Hagemann S, Günther T, Dennemärker J |title=The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. |journal=Eur. J. Cell Biol. |volume=83 |issue= 11-12 |pages= 775–80 |year= 2005 |pmid= 15679121 |doi=10.1078/0171-9335-00404  |display-authors=etal}}
*{{cite journal  | vauthors=Cheng T, Hitomi K, van Vlijmen-Willems IM |title=Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. |journal=J. Biol. Chem. |volume=281 |issue= 23 |pages= 15893–9 |year= 2006 |pmid= 16565075 |doi= 10.1074/jbc.M600694200 |display-authors=etal}}
*{{cite journal  | vauthors=Burden RE, Snoddy P, Jefferies CA |title=Inhibition of cathepsin L-like proteases by cathepsin V propeptide. |journal=Biol. Chem. |volume=388 |issue= 5 |pages= 541–5 |year= 2007 |pmid= 17516850 |doi= 10.1515/BC.2007.053 |display-authors=etal}}
*{{cite journal  | vauthors=Viken MK, Sollid HD, Joner G |title=Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis. |journal=Hum. Immunol. |volume=68 |issue= 9 |pages= 748–55 |year= 2007 |pmid= 17869649 |doi= 10.1016/j.humimm.2007.05.009 |display-authors=etal}}
}}
{{refend}}
{{PDB Gallery|geneid=1515}}

{{Cysteine proteases}}
{{Enzymes}}
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[[Category:Peptidase]]
[[Category:EC 3.4.22]]


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