View source for Microscopic polyangiitis overview

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{{Microscopic polyangiitis}}
{{CMG}} ; {{AE}} {{VKG}}
==Overview==
The early case reports of [[Microscopic polyangiitis]] provide a historical context and foundation for better understanding of the current concepts of these [[Disease|diseases]] Microscopic polyangiitis.[[Microscopic polyangiitis]] was first introduced by Dr. Friedrich Wohlwill, a German [[neuropathologist]], who described two patients with [[Transmural care|transmural]] periarteritis with [[glomerulonephritis]] in 1923.Historically, most forms of [[vasculitis]] like microscopic polyangiitis described subsequently classified on the basis of features similar to or distinct from [[polyarteritis]].According to The International Chapel Hill Consensus Conference (CHCC) criteria based on Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) into [[granulomatosis with polyangiitis]] (GPA), [[microscopic polyangiitis]] (MPA), including renal-limited vasculitis (RLV), and [[eosinophilic granulomatosis with polyangiitis]] (EGPA, [[Churg-Strauss syndrome|Churg-Strauss]]).The [[pathogenesis]] of [[Microscopic polyangiitis]] is currently not fully understood. However, certain [[Hypothesis|hypothesizes]] have been made to determine possible factors that may trigger the disease such as environmental factors and [[Anti-neutrophil cytoplasmic antibody|anti-neutrophil cytoplasmic antibodies.]] [[Capillary|Capillaries]] and [[venules]] are involved in the [[pathogenesis]] of [[microscopic polyangiitis]].The paucity of [[immunoglobulin]] deposition is shown in [[Immunohistochemical staining|Immunohistochemical]] staining.There are no known direct causes for [[Microscopic polyangiitis]].[[Microscopic polyangiitis]] can affect individuals from all ethnicities and of any [[age]] group.[[Vasculitis]] is a common term that refers to [[inflammation]] of the [[Blood vessel|blood vessels]] in the body.When the [[inflammation]] progress it lead to weakening and stretch of the [[Blood vessel|blood vessels]] and forms a an [[aneurysm]].Microscopic polyangiitis is not a [[cancer]], not [[contagious]], and it does not usually occur within families.The [[prevalence]] of [[Microscopic polyangiitis]] higher in Southern European countries and Asia.The incidence of GPA was similar to that of MPA.MPO‐[[Anti-neutrophil cytoplasmic antibody|ANCAs]] when positive in a patient was a marker of poor [[prognosis]] in the population of patients with AAV.Factors that are associated with the development of [[Microscopic polyangiitis]] is currently unknown. However, it has been suggested that environmental factors ([[silica]] exposure) may play a role.Currently, there are no [[Screening (medicine)|screening]] protocols for Microscopic polyangiitis.If left untreated, [[Microscopic polyangiitis]] can progress to end stage [[Renal insufficiency|renal failure]] and [[respiratory failure]]. Complications of [[Microscopic polyangiitis]] include, [[alveolar]] [[hemorrhage]], [[end stage renal failure]], [[Osteoarticular pain|osteoarticular]] disease, and [[infections]]. The [[prognosis]] of Microscopic polyangiitis. Obtaining a complete history is a critical aspect of making a clinical [[diagnosis]] of [[Microscopic polyangiitis]].As it can help differentiate between the [[Anti-neutrophil cytoplasmic antibody|Antineutrophil cytoplasmic antibodies]]([[ANCA]]) associated [[vasculitis]] and other possible causes that may [[Mimics|mimic]] the disease. There are many similarities that are present between [[ANCA]] associated [[vasculitis]] and [[Microscopic polyangiitis]]. A history and clinical [[Symptom|symptoms]] can help assess the disease. A complete medical history and comprehensive [[renal]], [[pulmonary]], and [[dermatological]] examination must be performed to help identify and properly diagnose [[Microscopic polyangiitis]] from other diseases.Obtaining a complete history is a critical aspect of making a clinical [[diagnosis]] of [[Microscopic polyangiitis]].As it can help differentiate between the [[Anti-neutrophil cytoplasmic antibody|Antineutrophil cytoplasmic antibodies]]([[ANCA]]) associated [[vasculitis]] and other possible causes that may [[Mimics|mimic]] the disease. There are many similarities that are present between [[ANCA]] associated [[vasculitis]] and [[Microscopic polyangiitis]]. A history and clinical [[Symptom|symptoms]] can help assess the disease.When suspecting a patient with microscopic polyangiitis(MPO) an [[Anti-neutrophil cytoplasmic antibody|ANCA]] test should be an idle choice.Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include [[leukocytosis]], elevated [[erythrocyte sedimentation rate]], [[proteinuria]], [[hematuria]], red cell casts, elevated blood [[urea]] [[nitrogen]], elevated serum [[creatinine]], and [[anti-neutrophil cytoplasmic antibodies]].There are no [[electrocardiogram]] findings associated with [[microscopic polyangiitis]].