View source for Transcortin

{{Protein
   |Name=Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
   |image=
   |caption=
   |Symbol=SERPINA6 
   |AltSymbols= CBG
   |HGNCid=1540
   |Chromosome=14
   |Arm=q
   |Band=32.1
   |LocusSupplementaryData=
   |ECnumber=
   |OMIM=122500
   |EntrezGene=866
   |RefSeq=NM_001750
   |UniProt=P08185
   |PDB=
}}
{{SI}}
{{CMG}}

{{EH}}
==Overview==
'''Transcortin''', also '''corticosteroid-binding globulin''' or '''CBG''', is officially called '''serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6'''. 

It is an [[alpha-globulin]].

==Binding==
Transcortin binds several proteins:

* [[Cortisol]]. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to [[serum albumin]].) The cortisol is thought to be biologically active only when it is not bound to transcortin.  

* [[Aldosterone]]. 60% of the aldosterone in blood is bound to this plasma protein. 

* [[Progesterone]]

==Production==
Transcortin is produced by the [[liver]] and is regulated by [[estrogen]]s.  Therefore, plasma transcortin levels increase during [[pregnancy]], and are decreased in [[cirrhosis]]. 

==See also==
* [[Sex hormone binding globulin]]
* [[Serpin]]

==External links==
* {{MeshName|Transcortin}}

{{Carrier proteins}}
{{Alpha globulins}}
{{Serpins}}
{{Glycoproteins}}
{{SIB}}

[[category:Glycoproteins]]

[[de:Transcortin]]
[[fr:Transcortine]]

[[Category:Proteins]]

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