View source for Adenylate kinase

{{Protein
   |Name=Adenylate kinase 1
   |image=
   |caption=
   |Symbol=AK1 
   |AltSymbols=
   |HGNCid=361
   |Chromosome=9
   |Arm=q
   |Band=34.1
   |LocusSupplementaryData=
   |ECnumber=2.7.4.3
   |OMIM=103000
   |EntrezGene=203
   |RefSeq=NM_000476
   |UniProt=P00568
   |PDB=
}}
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{{EH}}

==Overview==
'''Adenylate kinase''' (also known as '''ADK''' or '''myokinase''') is a [[phosphotransferase]] [[enzyme]] that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy [[homeostasis]] (see the [[Homeostasis#Biological homeostasis|"Biological homeostasis" section of "Homeostasis"]]).  The reaction catalyzed is:

 2 [[Adenosine diphosphate|ADP]] ⇔ [[Adenosine triphosphate|ATP]] + [[Adenosine monophosphate|AMP]]

The equilibrium constant in the direction written is 0.44. Thus, the ΔG<sup>o</sup> for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of [[ATP]] is typically 7-10 times that of [[ADP]], and usually greater than 100 times that of [[Adenosine monophosphate|AMP]] <ref>Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.</ref>. The rate of [[oxidative phosphorylation]] is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep [[ATP]] levels high due to the combined action of adenylate kinase and the controls on [[oxidative phosphorylation]].
===References===
{{Reflist}}
==External links==
* {{MeshName|Adenylate+kinase}}

[[Category:Cellular respiration]]
[[Category:EC 2.7.4]]

{{Kinases}}
{{Mitochondrial enzymes}}
{{SIB}}

[[ca:Mioquinasa]]
[[de:Adenylat-Kinase]]
[[es:Adenilato kinasa]]

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