View source for High triglyceride natural history, prognosis and complications

==Atherosclerosis and Cardiovascular Events==
It remains unclear if there is an independent association between hypertriglyceridemia and adverse cardiovascular outcomes <ref>Le NA, Walter MF. The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 2007; 9:110-5.</ref><ref>Stalenhoef AF, de Graaf J. Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL. Curr Opin Lipidol 2008; 19:355-61.</ref>).  The ascertainment of any independent association between hypertriglyceridemia and clinical outcomes is confounded by the fact that hypertriglyceridemia is associated with so many atherosclerotic risk factors including obesity, diabetes and [[insulin resistance]], [[metabolic syndrome]], the presence of other dyslipidemias associated themselves both with high triglycerides and atherosclerosis (e.g. [[mixed hyperlipidemia]], low HDL ([[hypoalphalipoproteinemia]]), [[Familial dysbetalipoproteinemia]] ([[type III hyperlipoproteinemia]]), etc.),  high levels of small, dense [[LDL]] and finally  high levels of [[apolipoprotein B]] (apoB).

For example, the relationship among hypertriglyceridemia, atherosclerosis, and apoB is complex. Specifically, those forms of hypertriglyceridemia associated with high levels of [[apoB]], but not those associated with low levels of apoB, are associated with atherosclerosis.<ref>Sniderman A, Couture P, de Graaf J. Diagnosis and treatment of apolipoprotein B dyslipoproteinemias. Nat Rev Endocrinol 2010; 6:335-46.</ref>