View source for Dicumarol

{{drugbox
| IUPAC_name = 3,3'-methylenebis(4-hydroxy-2''H''-chromen-2-one)
| image = Dicumarol_svg.png
| CAS_number = 66-76-2
| ATC_prefix = B01
| ATC_suffix = AA01
| ATC_supplemental = 
| PubChem = 653
| DrugBank = APRD00761
| C = 19 | H = 12 | O = 6
| molecular_weight = 336.295 g/mol
| bioavailability = 
| protein_bound = plasmatic proteins
| metabolism = hepatic
| elimination_half-life = 
| excretion = faeces, urine
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status = 
| routes_of_administration = 
}}
{{SI}}
{{WikiDoc Cardiology Network Infobox}}
{{CMG}}

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===[[Dicumarol (patient information)|For patient information, click here]]===

'''Dicumarol''' (or '''Dicoumarol''') is an [[anticoagulant]] that functions by as a [[Vitamin K]] antagonist (similar to [[warfarin]]).

It is a derivative of [[coumarin]].

==External links==
* {{DiseasesDB|30166}}
* {{cite journal | author = Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L | title = Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. | journal = Cancer Res | volume = 63 | issue = 17 | pages = 5513-20 | year = 2003 | id = PMID 14500388}}
* {{cite journal | author = Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A | title = Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport. | journal = Eur J Cell Biol | volume = 83 | issue = 6 | pages = 263-79 | year = 2004 | id = PMID 15511084}}
* {{cite journal | author = Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L | title = Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication. | journal = Arch Biochem Biophys | volume = 434 | issue = 2 | pages = 241-7 | year = 2005 | id = PMID 15639223}}
* {{cite journal | author = Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E | title = Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride. | journal = Pharm Res | volume = 20 | issue = 7 | pages = 1093-100 | year = 2003 | id = PMID 12880296}}


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