View source for C-Fos

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FOS_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a02.
 | PDB = 
 | Name = V-fos FBJ murine osteosarcoma viral oncogene homolog
 | HGNCid = 3796
 | Symbol = FOS
 | AltSymbols =; c-fos
 | OMIM = 164810
 | ECnumber =  
 | Homologene = 3844
 | MGIid = 95574
 | GeneAtlas_image1 = PBB_GE_FOS_209189_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} 
 | Process = {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2353
    | Hs_Ensembl = ENSG00000170345
    | Hs_RefseqProtein = NP_005243
    | Hs_RefseqmRNA = NM_005252
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 74815284
    | Hs_GenLoc_end = 74818685
    | Hs_Uniprot = P01100
    | Mm_EntrezGene = 14281
    | Mm_Ensembl = ENSMUSG00000021250
    | Mm_RefseqmRNA = NM_010234
    | Mm_RefseqProtein = NP_034364
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 86363004
    | Mm_GenLoc_end = 86366372
    | Mm_Uniprot = Q3U463
  }}
}}
{{SI}}


==Overview==
In [[molecular biology]], '''c-Fos''' is a cellular [[proto-oncogene]] belonging to the [[immediate early gene]] family of [[transcription factor]]s.  c-Fos has a [[leucine-zipper]] [[DNA]] binding domain, and a [[transactivation]] domain at the [[amino acid|C-terminus]].  Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. [[growth factor]]s.  Additionally, [[phosphorylation]] by [[Mitogen-activated protein kinase|MAPK]], [[Protein kinase A|PKA]], [[Protein kinase C|PKC]] or [[cdc2]] alters the activity and stability of c-Fos.  Members of the Fos family dimerise with [[Jun]] to form the [[AP-1]] transcription factor, which upregulates transcription of a diverse range of genes involved in everything from [[cell proliferation|proliferation]] and [[cell differentiation|differentiation]] to defense against invasion and cell damage.

The AP-1 complex has been implemented in [[transformation (cell division)|transformation]] and progression of [[cancer]], and both Fos and Jun were first discovered in rat [[fibroblast]]s.

The viral [[homology|homologue]] of c-Fos, [[v-Fos]], is found in the [[retrovirus]] [[Finkel–Biskis–Jinkins murine osteogenic sarcoma virus]].

== See also ==
*[[Leptomycin]]
*[[Jun]]
*[[Egr-1]]

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Murphy LC, Alkhalaf M, Dotzlaw H, ''et al.'' |title=Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins. |journal=Hum. Reprod. |volume=9 Suppl 1 |issue=  |pages= 174-80 |year= 1994 |pmid= 7962462 |doi=  }}
*{{cite journal  | author=Pompeiano M, Cirelli C, Arrighi P, Tononi G |title=c-Fos expression during wakefulness and sleep. |journal=Neurophysiologie clinique = Clinical neurophysiology |volume=25 |issue= 6 |pages= 329-41 |year= 1997 |pmid= 8904195 |doi= 10.1016/0987-7053(96)84906-9 }}
*{{cite journal  | author=Herrera DG, Robertson HA |title=Activation of c-fos in the brain. |journal=Prog. Neurobiol. |volume=50 |issue= 2-3 |pages= 83-107 |year= 1997 |pmid= 8971979 |doi=  }}
*{{cite journal  | author=Velazquez Torres A, Gariglio Vidal P |title=[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus] |journal=Rev. Invest. Clin. |volume=54 |issue= 3 |pages= 231-42 |year= 2002 |pmid= 12183893 |doi=  }}
}}
{{refend}}

==References==
# Karin Milde-Langosch, 2005. The Fos family of transcription factors and their role in tumourigenesis. ''European Journal of Cancer'' '''41'''(16):2449-2461. [http://dx.doi.org/10.1016/j.ejca.2005.08.008 Abstract + Full Text]

==External links==
* {{MeshName|c-fos+Proteins}}
* {{MeshName|c-fos+Genes}}


{{Oncogenes}}
{{Transcription factors}}

[[Category:Oncogenes]]
[[Category:Transcription factors]]

[[fr:C-Fos]]
[[pl:c-Fos]]
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