View source for Immune hemolytic anemia (patient information)

'''For the WikiDoc page for this topic, click [[Hemolytic anemia|here]]'''

{{Infobox_Disease
 | Name           = Hemolytic anemia
 | DiseasesDB     = 5534
 | ICD10          = D55-D59
 | ICD9           = {{ICD9|282}}, {{ICD9|283}}, {{ICD9|773}}
 | ICDO           = 
 | OMIM           = 
 | MedlinePlus    = 000576
 | MeshID         = 
}}

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'''Editor-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:mgibson@perfuse.org]  Phone:617-632-7753; '''Associate Editor-In-Chief:''' [[Lakshmi Gopalakrishnan]], M.B.B.S.

'''''Synonyms and Keywords:''''' Autoimmune hemolytic anemia, AIHA.

==Overview==
Immune hemolytic anemia is a condition in which there is a reduced blood cell count due to the '''premature destruction of red blood cells by the immune system.'''

==What are the symptoms of Immune hemolytic anemia?== 
*[[Dark urine]]
*[[Fatigue]]
*Pale ([[pallor]]) or yellow ([[jaundice]]) skin color
*Rapid heart rate
*[[Shortness of breath]]

==What causes Immune hemolytic anemia?==
*Immune hemolytic anemia occurs when '''antibodies form against the body's own red blood cells'''. The antibodies destroy the blood cells because the immune system mistakenly recognizes these blood cells as foreign material within the body.

*The antibodies may be caused by:
:*Complication of another disease
:*Past blood transfusions
:*[[Pregnancy]] (if the baby's blood type is different from the mother's)
:*Reaction to certain medications
:*Reaction to certain infections

*'''Secondary immune hemolytic anemia:''' If the cause of antibody formation is a disease or medication.

*'''Idiopathic autoimmune hemolytic anemia:''' accounts for one-half of all immune hemolytic anemias.

==Who is at highest risk?==
Risk factors are related to the causes.

==When to seek urgent medical care?==
Call your health care provider if you have unexplained [[fatigue]] or [[chest pain]], or signs of infection.

==Diagnosis==
*Absolute [[reticulocyte count]]
*Direct or indirect Coombs' test
*Hemoglobin in the urine
*LDH (level of this enzyme rises as a result of tissue damage)
*Red blood cell count (RBC), [[hemoglobin]], and [[hematocrit]]
*Serum [[bilirubin]] levels
*Serum free hemoglobin
*Serum [[haptoglobin]]

==Treatment options== 
*Treatment with a steroid medication such as '''[[prednisone]]''' is usually the first therapy tried. 

*If a steroid medication does not improve the condition, '''removal of the spleen''' (splenectomy) may be considered. Treatments with drugs that suppress the immune system ('''immunosuppressants''') may also be given if you do not respond to steroids.

*'''Blood transfusions''', if needed for severe anemia, are given with caution because the blood may not be compatible and it may cause further hemolysis.

==Where to find medical care for Immune hemolytic anemia?== 

[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|Immune hemolytic anemia}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating Immune hemolytic anemia] 

==Prevention==
'''Screening for antibodies in donated blood and in the recipient''' may prevent hemolytic anemia related to blood transfusions.

==What to expect (Outlook/Prognosis)?==
*The disease may start quickly and be very serious, or it may remain mild and not need specific treatment.

*In most people, steroids or splenectomy can control anemia.

*In others, treatment can usually partially control the anemia.

==Possible complications== 
*Severe anemia rarely leads to death. 
*'''Severe infection''' may occur as a complication of treatment with steroids, other medications that suppress the immune system, or splenectomy, because these treatments impair the body's ability to fight infection.

==See also==
*[[Hemolytic anemia (patient information)|Hemolytic Anemia]] 

*[[Drug induced hemolytic anemia (patient information)|Drug induced Hemolytic Anemia]]

*[[Non immune hemolytic anemia (patient information)|Non-immune Hemolytic Anemia]]

==Source==
http://www.nlm.nih.gov/medlineplus/ency/article/000576.htm


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[[Category:Disease]]
[[Category:Hematology]]
[[Category:Patient information]]
[[Category:Hematology patient information]]
[[Category:Mature chapter]]