View source for Interleukin-1 receptor



{{protein
| Name = [[interleukin 1 receptor, type I]]
| caption = 
| image = 
| width = 
| HGNCid = 5993
| Symbol = [[Interleukin 1 receptor, type I|IL1R1]]
| AltSymbols = IL1R, IL1RA
| EntrezGene = 3554
| OMIM = 147810
| RefSeq = NM_000877
| UniProt = P14778
| PDB = 
| ECnumber = 
| Chromosome = 2
| Arm = q
| Band = 12
| LocusSupplementaryData = 
}}
{{protein
| Name = [[interleukin 1 receptor, type II]]
| caption = 
| image = 
| width = 
| HGNCid = 5994
| Symbol = [[interleukin 1 receptor, type II|IL1R2]]
| AltSymbols = IL1RB
| EntrezGene = 7850
| OMIM = 147811
| RefSeq = NM_173343
| UniProt = P27930
| PDB = 
| ECnumber = 
| Chromosome = 2
| Arm = q
| Band = 12
| LocusSupplementaryData = 
}}
{{protein
| Name = [[IL1RAP|interleukin 1 receptor accessory protein]]
| caption = 
| image = 
| width = 
| HGNCid = 5995
| Symbol = [[IL1RAP]]
| AltSymbols = IL-1RAcP, IL1R3, C3orf13
| EntrezGene = 3556
| OMIM = 602626
| RefSeq = NM_134470
| UniProt = Q9NPH3
| PDB = 
| ECnumber = 
| Chromosome = 3
| Arm = q
| Band = 28
| LocusSupplementaryData = 
}}
'''Interleukin-1 receptor''' (IL-1R) is a [[cytokine receptor]] which binds [[interleukin 1]].<ref name="pmid7964161">{{cite journal | author = Kuno K, Matsushima K | title = The IL-1 receptor signaling pathway | journal = J. Leukoc. Biol. | volume = 56 | issue = 5 | pages = 542–7 | year = 1994 | pmid = 7964161 | doi = | issn = | url = http://www.jleukbio.org/cgi/content/abstract/56/5/542 | format = abstract page }}</ref>  Two forms of the receptor exist.  The [[interleukin 1 receptor, type I|type I]] receptor is primarily responsible for transmitting the [[inflammation|inflammatory]] effects of interleukin-1 (IL-1) while [[interleukin 1 receptor, type II|type II]] receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.<ref name="pmid7964161"/>  Also opposing the effects of IL-1 is the [[interleukin 1 receptor antagonist|IL-1 receptor antagonist]] (IL-1RA).<ref name="pmid1834696">{{cite journal | author = Arend WP | title = Interleukin 1 receptor antagonist. A new member of the interleukin 1 family | journal = J. Clin. Invest. | volume = 88 | issue = 5 | pages = 1445–51 | year = 1991 | pmid = 1834696 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1834696 }}</ref>

==References==
{{Reflist}}

==External links==
* {{MeshName|Receptors,+Interleukin-1}}


{{Immune receptors}}

[[Category:Cytokine receptors]]

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