View source for Lactoferrin

{{Protein
   |Symbol=LF
   |HGNCid=6720
   |AltSymbols=
   |EntrezGene=4057
   |OMIM=150210
   |RefSeq=NM_002343
   |UniProt=P02788
   |Chromosome=3
   |Arm=q
   |Band=21-23
   |LocusSupplementaryData=
   |AApro=703
   |AApre=711
}}
{{SI}}



'''Lactoferrin''' (LF), a [[globular protein|globular]] multifunctional protein with antimicrobial activity ([[bacteriocide]], [[fungicide]]), is part of the innate defense, mainly at mucoses. Lactoferrin is found in [[milk]] and many mucosal secretions such as [[tears]] and saliva. Lactoferrin is also present in secondary granules of [[neutrophil|PMN]] and also is secreted by some [[acinar cells]]. Human [[colostrum]] has the highest concentration, followed by human milk, then cow milk.

==Structure==
Lactoferrin belongs to the transferrin family proteins ([[transferrin|TF]], melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 [[atomic mass unit|u]] (80 [[dalton (unit)|kDa]]).

==Function==
Lactoferrin antimicrobial activity is due partly to its high affinity for [[iron|Fe]] (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.

Lactoferrin receptors have been found on brush-border cells, PMN, monocytes, [[macrophage|Mφ]] and activated lymphocytes.

==Genetics==
Genetically modified (transgenic) rice LL601 (Liberty Link 601) produces this protein.

==External links==
*[http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lac_0314.shtml Thompson.net] Supported information about lactoferrin.
*[http://www.fda.gov/bbs/topics/NEWS/2003/NEW00935.html FDA] Lactoferrin Considered Safe to Fight E. Coli.
*[http://www.lactoferrinresearch.org lactoferrinresearch.org]
*[http://www.Agennix.com Agennix.com] A biopharmaceutical company focused on developing protein-based drugs for cancer and diabetic ulcers.
*[http://www.pharming.com/index.php?act=prod&pg=11 Pharming.com] A biopharmaceutical company producing lactoferrin.


{{Globulins}}
{{Iron-binding proteins}}
{{Glycoproteins}}
[[Category:Proteins]]

[[es:lactoferrina]]
[[he:לקטופרין]]
[[ja:ラクトフェリン]]
[[pl:Laktoferyna]]

{{WikiDoc Help Menu}}
{{WikiDoc Sources}}