View source for Transient receptor potential channel



'''Transient receptor potential''' or '''TRP''' channels are a family of loosely related [[ion channel]]s that are non-selectively permeable to [[cation]]s, including [[calcium]] and [[magnesium]]. TRP channels are so named because they were discovered in mutant [[Drosophila]] that, instead of having sustained [[photoreceptor]] activity in response to light, had only a transient response to light.<ref name="pmid810728">{{cite journal |author=Minke B, Wu C, Pak WL |title=Induction of photoreceptor voltage noise in the dark in Drosophila mutant |journal=Nature |volume=258 |issue=5530 |pages=84-7 |year=1975 |pmid=810728 |doi=10.1038/258084a0}}</ref> Most TRP channels are comprised of 6 membrane-spanning helices with intracellular N- and C-termini. TRP channels are activated and regulated by a wide variety of stimuli and are expressed widely throughout the body.

==Genes==
They are encoded by at least 33 channel subunit [[gene]]s divided into seven sub-families: 
* [[TRPC]] ('''c'''anonical) - associated with [[Focal segmental glomerulosclerosis]] 
* [[TRPV]] ('''v'''anilloid) 
* [[TRPA (channel)|TRPA]] ('''a'''nkyrin) 
* [[TRPM]] ('''m'''elastatin) -- associated with [[Hypomagnesemia with secondary hypocalcemia]]
* [[TRPP]] ('''p'''olycystin) -- associated with [[Polycystic kidney disease]]
* [[TRPML]] ('''m'''uco'''l'''ipin) -- associated with [[Mucolipidosis type IV]]
* [[TRPN]] ('''N'''OMPC) - '''n'''o mechanoreceptor potential C - not found in mammals

== References ==
{{reflist}}

==External links==
*[http://www.iuphar-db.org/iuphar-ic/TRPM/TRPMIntro.pdf IUPHAR]
*{{MeshName|Transient+Receptor+Potential+Channels}}

{{Ion channels}}
[[Category:Membrane biology]]
[[Category:Ion channels]]

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