View source for ABCA1

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = ATP-binding cassette, sub-family A (ABC1), member 1
 | HGNCid = 29
 | Symbol = ABCA1
 | AltSymbols =; ABC-1; ABC1; CERP; FLJ14958; HDLDT1; TGD
 | OMIM = 600046
 | ECnumber =  
 | Homologene = 21130
 | MGIid = 99607
 | GeneAtlas_image1 = PBB_GE_ABCA1_203504_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ABCA1_216066_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008509 |text = anion transmembrane transporter activity}} {{GNF_GO|id=GO:0015248 |text = sterol transporter activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006911 |text = phagocytosis, engulfment}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0030301 |text = cholesterol transport}} {{GNF_GO|id=GO:0042158 |text = lipoprotein biosynthetic process}} {{GNF_GO|id=GO:0045332 |text = phospholipid translocation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 19
    | Hs_Ensembl = ENSG00000165029
    | Hs_RefseqProtein = NP_005493
    | Hs_RefseqmRNA = NM_005502
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 106583104
    | Hs_GenLoc_end = 106730339
    | Hs_Uniprot = O95477
    | Mm_EntrezGene = 11303
    | Mm_Ensembl = ENSMUSG00000015243
    | Mm_RefseqmRNA = NM_013454
    | Mm_RefseqProtein = NP_038482
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 53051888
    | Mm_GenLoc_end = 53180992
    | Mm_Uniprot = Q8BPY1
  }}
}}
'''ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA'''is a human protein and [[gene]]. This transporter is a major regulator of cellular [[cholesterol]] and [[phospholipid]] [[homeostasis]].

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{{PBB_Summary
| section_title = 
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of [[ATP-binding cassette transporter|ATP-binding cassette (ABC) transporters]].  ABC proteins transport various molecules across extra- and intracellular membranes.  ABC genes are divided into seven distinct subfamilies (ABCA, MDR/TAP, MRP, ALD, OABP, GCN20, White).  This protein is a member of the ABCA subfamily.  Members of the ABCA subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.  With cholesterol as its substrate, this protein functions as a cholesterol [[efflux]] pump in the cellular lipid removal pathway.  Mutations in this gene have been associated with [[Tangier's disease]] and familial [[high-density lipoprotein]] deficiency.<ref>{{cite web | title = Entrez Gene: ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=19| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Oram JF |title=ATP-binding cassette transporter A1 and cholesterol trafficking. |journal=Curr. Opin. Lipidol. |volume=13 |issue= 4 |pages= 373-81 |year= 2003 |pmid= 12151852 |doi=  }}
*{{cite journal  | author=Hong SH, Rhyne J, Zeller K, Miller M |title=ABCA1(Alabama): a novel variant associated with HDL deficiency and premature coronary artery disease. |journal=Atherosclerosis |volume=164 |issue= 2 |pages= 245-50 |year= 2003 |pmid= 12204794 |doi=  }}
*{{cite journal  | author=Kozak M |title=Emerging links between initiation of translation and human diseases. |journal=Mamm. Genome |volume=13 |issue= 8 |pages= 401-10 |year= 2003 |pmid= 12226704 |doi= 10.1007/s00335-002-4002-5 }}
*{{cite journal  | author=Joyce C, Freeman L, Brewer HB, Santamarina-Fojo S |title=Study of ABCA1 function in transgenic mice. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 6 |pages= 965-71 |year= 2004 |pmid= 12615681 |doi= 10.1161/01.ATV.0000055194.85073.FF }}
*{{cite journal  | author=Singaraja RR, Brunham LR, Visscher H, ''et al.'' |title=Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 8 |pages= 1322-32 |year= 2004 |pmid= 12763760 |doi= 10.1161/01.ATV.0000078520.89539.77 }}
*{{cite journal  | author=Nofer JR, Remaley AT |title=Tangier disease: still more questions than answers. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 19-20 |pages= 2150-60 |year= 2005 |pmid= 16235041 |doi= 10.1007/s00018-005-5125-0 }}
*{{cite journal  | author=Yokoyama S |title=ABCA1 and biogenesis of HDL. |journal=J. Atheroscler. Thromb. |volume=13 |issue= 1 |pages= 1-15 |year= 2006 |pmid= 16505586 |doi=  }}
*{{cite journal  | author=Schmitz G, Schambeck CM |title=Molecular defects in the ABCA1 pathway affect platelet function. |journal=Pathophysiol. Haemost. Thromb. |volume=35 |issue= 1-2 |pages= 166-74 |year= 2006 |pmid= 16855366 |doi= 10.1159/000093563 }}
}}
{{refend}}

{{protein-stub}}
{{Membrane transport proteins}}
[[Category:ABC transporters]]
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