View source for AMY2B

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_AMY2B_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b2y.
 | PDB = {{PDB2|1b2y}}, {{PDB2|1bsi}}, {{PDB2|1c8q}}, {{PDB2|1cpu}}, {{PDB2|1hny}}, {{PDB2|1jxj}}, {{PDB2|1jxk}}, {{PDB2|1kb3}}, {{PDB2|1kbb}}, {{PDB2|1kbk}}, {{PDB2|1kgu}}, {{PDB2|1kgw}}, {{PDB2|1kgx}}, {{PDB2|1mfu}}, {{PDB2|1mfv}}, {{PDB2|1nm9}}, {{PDB2|1q4n}}, {{PDB2|1smd}}, {{PDB2|1u2y}}, {{PDB2|1u30}}, {{PDB2|1u33}}, {{PDB2|1xcw}}, {{PDB2|1xcx}}, {{PDB2|1xd0}}, {{PDB2|1xd1}}, {{PDB2|1xgz}}, {{PDB2|1xh0}}, {{PDB2|1xh1}}, {{PDB2|1xh2}}, {{PDB2|1xv8}}, {{PDB2|1z32}}, {{PDB2|2cpu}}, {{PDB2|3cpu}}
 | Name = Amylase, alpha 2B (pancreatic)
 | HGNCid = 478
 | Symbol = AMY2B
 | AltSymbols =; AMY2
 | OMIM = 104660
 | ECnumber =  
 | Homologene = 88874
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_AMY2B_208498_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004556 |text = alpha-amylase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}} {{GNF_GO|id=GO:0031404 |text = chloride ion binding}} 
 | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 280
    | Hs_Ensembl = ENSG00000197839
    | Hs_RefseqProtein = NP_066188
    | Hs_RefseqmRNA = NM_020978
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 103897960
    | Hs_GenLoc_end = 103923675
    | Hs_Uniprot = P19961
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Amylase, alpha 2B (pancreatic)''', also known as '''AMY2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.<ref name="entrez">{{cite web | title = Entrez Gene: AMY2B amylase, alpha 2B (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=280| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Kaczmarek MJ, Rosenmund H |title=The action of human pancreatic and salivary isoamylases on starch and glycogen. |journal=Clin. Chim. Acta |volume=79 |issue= 1 |pages= 69-73 |year= 1977 |pmid= 890964 |doi=  }}
*{{cite journal  | author=Groot PC, Mager WH, Henriquez NV, ''et al.'' |title=Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers. |journal=Genomics |volume=8 |issue= 1 |pages= 97-105 |year= 1991 |pmid= 2081604 |doi=  }}
*{{cite journal  | author=Yokouchi H, Horii A, Emi M, ''et al.'' |title=Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. |journal=Gene |volume=90 |issue= 2 |pages= 281-6 |year= 1990 |pmid= 2401405 |doi=  }}
*{{cite journal  | author=Gumucio DL, Wiebauer K, Caldwell RM, ''et al.'' |title=Concerted evolution of human amylase genes. |journal=Mol. Cell. Biol. |volume=8 |issue= 3 |pages= 1197-205 |year= 1988 |pmid= 2452973 |doi=  }}
*{{cite journal  | author=Samuelson LC, Wiebauer K, Gumucio DL, Meisler MH |title=Expression of the human amylase genes: recent origin of a salivary amylase promoter from an actin pseudogene. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8261-76 |year= 1988 |pmid= 2458567 |doi=  }}
*{{cite journal  | author=Tomita N, Horii A, Doi S, ''et al.'' |title=A novel type of human alpha-amylase produced in lung carcinoid tumor. |journal=Gene |volume=76 |issue= 1 |pages= 11-8 |year= 1989 |pmid= 2701942 |doi=  }}
*{{cite journal  | author=Groot PC, Bleeker MJ, Pronk JC, ''et al.'' |title=The human alpha-amylase multigene family consists of haplotypes with variable numbers of genes. |journal=Genomics |volume=5 |issue= 1 |pages= 29-42 |year= 1989 |pmid= 2788608 |doi=  }}
*{{cite journal  | author=Groot PC, Bleeker MJ, Pronk JC, ''et al.'' |title=Human pancreatic amylase is encoded by two different genes. |journal=Nucleic Acids Res. |volume=16 |issue= 10 |pages= 4724 |year= 1988 |pmid= 3260028 |doi=  }}
*{{cite journal  | author=Tricoli JV, Shows TB |title=Regional assignment of human amylase (AMY) to p22----p21 of chromosome 1. |journal=Somat. Cell Mol. Genet. |volume=10 |issue= 2 |pages= 205-10 |year= 1984 |pmid= 6608795 |doi=  }}
*{{cite journal  | author=Omichi K, Hase S |title=Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. |journal=Biochim. Biophys. Acta |volume=1203 |issue= 2 |pages= 224-9 |year= 1994 |pmid= 8268204 |doi=  }}
*{{cite journal  | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi=  }}
*{{cite journal  | author=Aughsteen AA |title=A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas. |journal=Saudi medical journal |volume=22 |issue= 5 |pages= 410-5 |year= 2001 |pmid= 11376382 |doi=  }}
*{{cite journal  | author=Koyama I, Komine S, Iino N, ''et al.'' |title=alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues. |journal=Clin. Chim. Acta |volume=309 |issue= 1 |pages= 73-83 |year= 2001 |pmid= 11408008 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Iafrate AJ, Feuk L, Rivera MN, ''et al.'' |title=Detection of large-scale variation in the human genome. |journal=Nat. Genet. |volume=36 |issue= 9 |pages= 949-51 |year= 2004 |pmid= 15286789 |doi= 10.1038/ng1416 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
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