View source for Casein kinase 2

The '''Casein kinase 2''' ({{EC number|2.7.11.1}}) is a [[serine]]/[[threonine]]-selective [[protein kinase]] that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in [[cell cycle]] control, [[DNA repair]], regulation of the [[circadian rhythm]] and other cellular processes.
{{proteinShort | Name = casein kinase 2, alpha 1 polypeptide | caption = | image = | width = | HGNCid = 2457 | Symbol = CSNK2A1 | AltSymbols = | EntrezGene = 1457 | OMIM = 115440 | RefSeq = NM_001895 | UniProt = P68400 | PDB = | ECnumber = | Chromosome = 20 | Arm = p | Band = 13 | LocusSupplementaryData = }}
{{proteinShort | Name = casein kinase 2, alpha prime polypeptide | caption = | image = | width = | HGNCid = 2459 | Symbol = CSNK2A2 | AltSymbols = | EntrezGene = 1459 | OMIM = 115442 | RefSeq = NM_001896 | UniProt = P19784 | PDB = | ECnumber = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}
{{proteinShort | Name = casein kinase 2, beta polypeptide | caption = | image = | width = | HGNCid = 2460 | Symbol = CSNK2B | AltSymbols = | EntrezGene = 1460 | OMIM = 115441 | RefSeq = NM_001320 | UniProt = P67870 | PDB = | ECnumber = 2.7.1.37 | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}

Casein kinase 2 activity has been reported to be activated following [[Wnt signaling pathway]] activation<ref>Y. Gao and H. Y. Wang (2006) "Casein kinase 2 is activated and essential for wnt/beta-catenin signaling" in ''Journal of Biological Chemistry'' {{Entrez Pubmed|16672224}}</ref>.
A [[Pertussis toxin]]-sensitive [[GTPase#Heterotrimeric G proteins|G protein]] and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphlogy of developing [[spermatozoon|sperm]] <ref>X. Xu, P. Toselli, L. Russell and D. Seldin (1999) "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit" in ''Nature Genetics'' Volume 23, pages 118-121. {{Entrez Pubmed|10471512}}</ref>

==See also==
*[[Casein kinase 1]] - a distinct protein kinase family

==References==
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{{Template:Cell_signaling}}

[[Category:Signal transduction]]
[[Category:Protein kinases]]
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