View source for FOSB

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = FBJ murine osteosarcoma viral oncogene homolog B
 | HGNCid = 3797
 | Symbol = FOSB
 | AltSymbols =; DKFZp686C0818; G0S3; GOS3; GOSB; MGC42291
 | OMIM = 164772
 | ECnumber =  
 | Homologene = 31403
 | MGIid = 95575
 | GeneAtlas_image1 = PBB_GE_FOSB_202768_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007610 |text = behavior}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2354
    | Hs_Ensembl = ENSG00000125740
    | Hs_RefseqProtein = NP_006723
    | Hs_RefseqmRNA = NM_006732
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50663093
    | Hs_GenLoc_end = 50670254
    | Hs_Uniprot = P53539
    | Mm_EntrezGene = 14282
    | Mm_Ensembl = ENSMUSG00000003545
    | Mm_RefseqmRNA = NM_008036
    | Mm_RefseqProtein = NP_032062
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18463363
    | Mm_GenLoc_end = 18467953
    | Mm_Uniprot = P13346
  }}
}}


==Overview==
'''FBJ murine osteosarcoma viral oncogene homolog B''' (also known as '''FOSB''' or '''FosB''') is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSB FBJ murine osteosarcoma viral oncogene homolog B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2354| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSB FBJ murine osteosarcoma viral oncogene homolog B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2354| accessdate = }}</ref>
}}

==Delta FosB==
'''Delta FosB''' is a truncated [[splice variant]] of FosB. Delta FosB has been implicated in the development of [[drug addiction]] and control of the [[reward system]] in the [[brain]].<ref name="Werme">{{cite journal |author=Werme M, Messer C, Olson L, ''et al'' |title=Delta FosB regulates wheel running |journal=J. Neurosci. |volume=22 |issue=18 |pages=8133–8 |year=2002 |pmid=12223567 |doi=}}</ref>

==See also==
* [[AP-1 (transcription factor)]]

==References==
{{reflist|2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Martin-Gallardo A, McCombie WR, Gocayne JD, ''et al.'' |title=Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. |journal=Nat. Genet. |volume=1 |issue= 1 |pages= 34-9 |year= 1993 |pmid= 1301997 |doi= 10.1038/ng0492-34 }}
*{{cite journal  | author=Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR |title=A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. |journal=DNA Cell Biol. |volume=9 |issue= 8 |pages= 579-87 |year= 1991 |pmid= 1702972 |doi=  }}
*{{cite journal  | author=Nakabeppu Y, Nathans D |title=A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. |journal=Cell |volume=64 |issue= 4 |pages= 751-9 |year= 1991 |pmid= 1900040 |doi=  }}
*{{cite journal  | author=Schuermann M, Jooss K, Müller R |title=fosB is a transforming gene encoding a transcriptional activator. |journal=Oncogene |volume=6 |issue= 4 |pages= 567-76 |year= 1991 |pmid= 1903195 |doi=  }}
*{{cite journal  | author=Brown JR, Ye H, Bronson RT, ''et al.'' |title=A defect in nurturing in mice lacking the immediate early gene fosB. |journal=Cell |volume=86 |issue= 2 |pages= 297-309 |year= 1996 |pmid= 8706134 |doi=  }}
*{{cite journal  | author=Heximer SP, Cristillo AD, Russell L, Forsdyke DR |title=Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3). |journal=DNA Cell Biol. |volume=15 |issue= 12 |pages= 1025-38 |year= 1997 |pmid= 8985116 |doi=  }}
*{{cite journal  | author=Liberati NT, Datto MB, Frederick JP, ''et al.'' |title=Smads bind directly to the Jun family of AP-1 transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4844-9 |year= 1999 |pmid= 10220381 |doi=  }}
*{{cite journal  | author=Yamamura Y, Hua X, Bergelson S, Lodish HF |title=Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36295-302 |year= 2000 |pmid= 10942775 |doi= 10.1074/jbc.M006023200 }}
*{{cite journal  | author=Bergman MR, Cheng S, Honbo N, ''et al.'' |title=A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 485-96 |year= 2003 |pmid= 12371906 |doi= 10.1042/BJ20020707 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Milde-Langosch K, Kappes H, Riethdorf S, ''et al.'' |title=FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomas. |journal=Breast Cancer Res. Treat. |volume=77 |issue= 3 |pages= 265-75 |year= 2003 |pmid= 12602926 |doi=  }}
*{{cite journal  | author=Baumann S, Hess J, Eichhorst ST, ''et al.'' |title=An unexpected role for FosB in activation-induced cell death of T cells. |journal=Oncogene |volume=22 |issue= 9 |pages= 1333-9 |year= 2003 |pmid= 12618758 |doi= 10.1038/sj.onc.1206126 }}
*{{cite journal  | author=Holmes DI, Zachary I |title=Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. |journal=FEBS Lett. |volume=557 |issue= 1-3 |pages= 93-8 |year= 2004 |pmid= 14741347 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Konsman JP, Blomqvist A |title=Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat. |journal=Eur. J. Neurosci. |volume=21 |issue= 10 |pages= 2752-66 |year= 2005 |pmid= 15926923 |doi= 10.1111/j.1460-9568.2005.04102.x }}
}}
{{refend}}

== External links ==
* {{MeshName|FOSB+protein,+human}}

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{{Transcription factors}}
[[Category:Transcription factors]]
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