View source for GUCY1B3

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Guanylate cyclase 1, soluble, beta 3
 | HGNCid = 4687
 | Symbol = GUCY1B3
 | AltSymbols =; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3
 | OMIM = 139397
 | ECnumber =  
 | Homologene = 664
 | MGIid = 1860604
 | GeneAtlas_image1 = PBB_GE_GUCY1B3_211555_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004383 |text = guanylate cyclase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008074 |text = guanylate cyclase complex, soluble}} 
 | Process = {{GNF_GO|id=GO:0006182 |text = cGMP biosynthetic process}} {{GNF_GO|id=GO:0007263 |text = nitric oxide mediated signal transduction}} {{GNF_GO|id=GO:0008015 |text = circulation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2983
    | Hs_Ensembl = ENSG00000061918
    | Hs_RefseqProtein = NP_000848
    | Hs_RefseqmRNA = NM_000857
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 156899661
    | Hs_GenLoc_end = 156951636
    | Hs_Uniprot = Q02153
    | Mm_EntrezGene = 54195
    | Mm_Ensembl = ENSMUSG00000028005
    | Mm_RefseqmRNA = NM_017469
    | Mm_RefseqProtein = NP_059497
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 82119182
    | Mm_GenLoc_end = 82159998
    | Mm_Uniprot = Q3UTI4
  }}
}}
'''Guanylate cyclase 1, soluble, beta 3''', also known as '''GUCY1B3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lucas KA, Pitari GM, Kazerounian S, ''et al.'' |title=Guanylyl cyclases and signaling by cyclic GMP. |journal=Pharmacol. Rev. |volume=52 |issue= 3 |pages= 375-414 |year= 2000 |pmid= 10977868 |doi=  }}
*{{cite journal  | author=Giuili G, Scholl U, Bulle F, Guellaën G |title=Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. |journal=FEBS Lett. |volume=304 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1352257 |doi=  }}
*{{cite journal  | author=Chhajlani V, Frändberg PA, Ahlner J, ''et al.'' |title=Heterogeneity in human soluble guanylate cyclase due to alternative splicing. |journal=FEBS Lett. |volume=290 |issue= 1-2 |pages= 157-8 |year= 1991 |pmid= 1680753 |doi=  }}
*{{cite journal  | author=Giuili G, Roechel N, Scholl U, ''et al.'' |title=Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33. |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 257-60 |year= 1993 |pmid= 8097486 |doi=  }}
*{{cite journal  | author=Papapetropoulos A, Cziraki A, Rubin JW, ''et al.'' |title=cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. |journal=J. Cell. Physiol. |volume=167 |issue= 2 |pages= 213-21 |year= 1996 |pmid= 8613461 |doi= 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
*{{cite journal  | author=Zabel U, Weeger M, La M, Schmidt HH |title=Human soluble guanylate cyclase: functional expression and revised isoenzyme family. |journal=Biochem. J. |volume=335 ( Pt 1) |issue=  |pages= 51-7 |year= 1998 |pmid= 9742212 |doi=  }}
*{{cite journal  | author=Russwurm M, Wittau N, Koesling D |title=Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44647-52 |year= 2002 |pmid= 11572861 |doi= 10.1074/jbc.M105587200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Venema RC, Venema VJ, Ju H, ''et al.'' |title=Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 2 |pages= H669-78 |year= 2003 |pmid= 12676772 |doi= 10.1152/ajpheart.01025.2002 }}
*{{cite journal  | author=Meurer S, Pioch S, Wagner K, ''et al.'' |title=AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49346-54 |year= 2005 |pmid= 15381706 |doi= 10.1074/jbc.M410565200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, ''et al.'' |title=Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. |journal=Int. J. Impot. Res. |volume=18 |issue= 5 |pages= 432-7 |year= 2006 |pmid= 16528291 |doi= 10.1038/sj.ijir.3901461 }}
}}
{{refend}}

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