View source for MSH5

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = MutS homolog 5 (E. coli)
 | HGNCid = 7328
 | Symbol = MSH5
 | AltSymbols =; DKFZp434C1615; G7; MGC2939; MutSH5; NG23
 | OMIM = 603382
 | ECnumber =  
 | Homologene = 8415
 | MGIid = 1329021
 | GeneAtlas_image1 = PBB_GE_MSH5_210410_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MSH5_221406_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_MSH5_212913_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006298 |text = mismatch repair}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0007131 |text = meiotic recombination}} {{GNF_GO|id=GO:0007136 |text = meiotic prophase II}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4439
    | Hs_Ensembl = ENSG00000096474
    | Hs_RefseqProtein = XP_001131770
    | Hs_RefseqmRNA = XM_001131770
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 31842436
    | Hs_GenLoc_end = 31867259
    | Hs_Uniprot = Q5SSQ6
    | Mm_EntrezGene = 17687
    | Mm_Ensembl = ENSMUSG00000007035
    | Mm_RefseqmRNA = NM_013600
    | Mm_RefseqProtein = NP_038628
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34636661
    | Mm_GenLoc_end = 34654782
    | Mm_Uniprot = Q9R1I5
  }}
}}
'''MutS homolog 5 (E. coli)''', also known as '''MSH5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MSH5 mutS homolog 5 (E. coli)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4439| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: MSH5 mutS homolog 5 (E. coli)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4439| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Her C, Zhao N, Wu X, Tompkins JD |title=MutS homologues hMSH4 and hMSH5: diverse functional implications in humans. |journal=Front. Biosci. |volume=12 |issue=  |pages= 905-11 |year= 2007 |pmid= 17127347 |doi=  }}
*{{cite journal  | author=Sargent CA, Dunham I, Campbell RD |title=Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region. |journal=EMBO J. |volume=8 |issue= 8 |pages= 2305-12 |year= 1989 |pmid= 2477242 |doi=  }}
*{{cite journal  | author=Albertella MR, Jones H, Thomson W, ''et al.'' |title=Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). |journal=Genomics |volume=36 |issue= 2 |pages= 240-51 |year= 1997 |pmid= 8812450 |doi= 10.1006/geno.1996.0459 }}
*{{cite journal  | author=Her C, Doggett NA |title=Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. |journal=Genomics |volume=52 |issue= 1 |pages= 50-61 |year= 1999 |pmid= 9740671 |doi= 10.1006/geno.1998.5374 }}
*{{cite journal  | author=Winand NJ, Panzer JA, Kolodner RD |title=Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. |journal=Genomics |volume=53 |issue= 1 |pages= 69-80 |year= 1998 |pmid= 9787078 |doi= 10.1006/geno.1998.5447 }}
*{{cite journal  | author=Edelmann W, Cohen PE, Kneitz B, ''et al.'' |title=Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. |journal=Nat. Genet. |volume=21 |issue= 1 |pages= 123-7 |year= 1999 |pmid= 9916805 |doi= 10.1038/5075 }}
*{{cite journal  | author=Bocker T, Barusevicius A, Snowden T, ''et al.'' |title=hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis. |journal=Cancer Res. |volume=59 |issue= 4 |pages= 816-22 |year= 1999 |pmid= 10029069 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
*{{cite journal  | author=Snowden T, Acharya S, Butz C, ''et al.'' |title=hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes. |journal=Mol. Cell |volume=15 |issue= 3 |pages= 437-51 |year= 2004 |pmid= 15304223 |doi= 10.1016/j.molcel.2004.06.040 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Yi W, Wu X, Lee TH, ''et al.'' |title=Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 2 |pages= 524-32 |year= 2005 |pmid= 15907804 |doi= 10.1016/j.bbrc.2005.04.154 }}
*{{cite journal  | author=Lee TH, Yi W, Griswold MD, ''et al.'' |title=Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. |journal=DNA Repair (Amst.) |volume=5 |issue= 1 |pages= 32-42 |year= 2006 |pmid= 16122992 |doi= 10.1016/j.dnarep.2005.07.004 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Sekine H, Ferreira RC, Pan-Hammarström Q, ''et al.'' |title=Role for Msh5 in the regulation of Ig class switch recombination. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 17 |pages= 7193-8 |year= 2007 |pmid= 17409188 |doi= 10.1073/pnas.0700815104 }}
*{{cite journal  | author=Szafranski K, Schindler S, Taudien S, ''et al.'' |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= |volume=8 |issue= 8 |pages= R154 |year=  |pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154 }}
}}
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