View source for SLC10A2

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Solute carrier family 10 (sodium/bile acid cotransporter family), member 2
 | HGNCid = 10906
 | Symbol = SLC10A2
 | AltSymbols =; ASBT; ISBT; NTCP2
 | OMIM = 601295
 | ECnumber =  
 | Homologene = 390
 | MGIid = 1201406
 | GeneAtlas_image1 = PBB_GE_SLC10A2_207095_at_tn.png
 | Function = {{GNF_GO|id=GO:0008508 |text = bile acid:sodium symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0015711 |text = organic anion transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6555
    | Hs_Ensembl = ENSG00000125255
    | Hs_RefseqProtein = NP_000443
    | Hs_RefseqmRNA = NM_000452
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 102494351
    | Hs_GenLoc_end = 102517197
    | Hs_Uniprot = Q12908
    | Mm_EntrezGene = 20494
    | Mm_Ensembl = ENSMUSG00000023073
    | Mm_RefseqmRNA = NM_011388
    | Mm_RefseqProtein = NP_035518
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 5085595
    | Mm_GenLoc_end = 5105204
    | Mm_Uniprot = Q0VBB8
  }}
}}
'''Solute carrier family 10 (sodium/bile acid cotransporter family), member 2''', also known as '''SLC10A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6555| accessdate = }}</ref>

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{{PBB_Summary
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| summary_text = 
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==See also==
* [[Solute carrier family]]

==References==
{{reflist|2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Shneider BL |title=Intestinal bile acid transport: biology, physiology, and pathophysiology. |journal=J. Pediatr. Gastroenterol. Nutr. |volume=32 |issue= 4 |pages= 407-17 |year= 2001 |pmid= 11396803 |doi=  }}
*{{cite journal  | author=Balakrishnan A, Polli JE |title=Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target. |journal=Mol. Pharm. |volume=3 |issue= 3 |pages= 223-30 |year= 2006 |pmid= 16749855 |doi= 10.1021/mp060022d }}
*{{cite journal  | author=Wong MH, Oelkers P, Dawson PA |title=Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27228-34 |year= 1995 |pmid= 7592981 |doi=  }}
*{{cite journal  | author=Wong MH, Rao PN, Pettenati MJ, Dawson PA |title=Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33. |journal=Genomics |volume=33 |issue= 3 |pages= 538-40 |year= 1996 |pmid= 8661017 |doi= 10.1006/geno.1996.0233 }}
*{{cite journal  | author=Oelkers P, Kirby LC, Heubi JE, Dawson PA |title=Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). |journal=J. Clin. Invest. |volume=99 |issue= 8 |pages= 1880-7 |year= 1997 |pmid= 9109432 |doi=  }}
*{{cite journal  | author=Craddock AL, Love MW, Daniel RW, ''et al.'' |title=Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. |journal=Am. J. Physiol. |volume=274 |issue= 1 Pt 1 |pages= G157-69 |year= 1998 |pmid= 9458785 |doi=  }}
*{{cite journal  | author=Montagnani M, Love MW, Rössel P, ''et al.'' |title=Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. |journal=Scand. J. Gastroenterol. |volume=36 |issue= 10 |pages= 1077-80 |year= 2002 |pmid= 11589382 |doi=  }}
*{{cite journal  | author=Love MW, Craddock AL, Angelin B, ''et al.'' |title=Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=21 |issue= 12 |pages= 2039-45 |year= 2002 |pmid= 11742882 |doi=  }}
*{{cite journal  | author=Jung D, Fried M, Kullak-Ublick GA |title=Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30559-66 |year= 2002 |pmid= 12055195 |doi= 10.1074/jbc.M203511200 }}
*{{cite journal  | author=Zelcer N, Saeki T, Bot I, ''et al.'' |title=Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. |journal=Biochem. J. |volume=369 |issue= Pt 1 |pages= 23-30 |year= 2003 |pmid= 12220224 |doi= 10.1042/BJ20021081 }}
*{{cite journal  | author=Chumakov I, Blumenfeld M, Guerassimenko O, ''et al.'' |title=Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13675-80 |year= 2002 |pmid= 12364586 |doi= 10.1073/pnas.182412499 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  | author=Neimark E, Chen F, Li X, Shneider BL |title=Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. |journal=Hepatology |volume=40 |issue= 1 |pages= 149-56 |year= 2004 |pmid= 15239098 |doi= 10.1002/hep.20295 }}
*{{cite journal  | author=Xia X, Roundtree M, Merikhi A, ''et al.'' |title=Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44931-7 |year= 2004 |pmid= 15304498 |doi= 10.1074/jbc.M400969200 }}
*{{cite journal  | author=Zhang EY, Phelps MA, Banerjee A, ''et al.'' |title=Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2). |journal=Biochemistry |volume=43 |issue= 36 |pages= 11380-92 |year= 2004 |pmid= 15350125 |doi= 10.1021/bi049270a }}
*{{cite journal  | author=Banerjee A, Ray A, Chang C, Swaan PW |title=Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2). |journal=Biochemistry |volume=44 |issue= 24 |pages= 8908-17 |year= 2005 |pmid= 15952798 |doi= 10.1021/bi050553s }}
*{{cite journal  | author=Nakahara M, Furuya N, Takagaki K, ''et al.'' |title=Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. |journal=J. Biol. Chem. |volume=280 |issue= 51 |pages= 42283-9 |year= 2006 |pmid= 16230354 |doi= 10.1074/jbc.M507454200 }}
*{{cite journal  | author=Bergheim I, Harsch S, Mueller O, ''et al.'' |title=Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. |journal=J. Lipid Res. |volume=47 |issue= 1 |pages= 42-50 |year= 2006 |pmid= 16237211 |doi= 10.1194/jlr.M500215-JLR200 }}
*{{cite journal  | author=Banerjee A, Swaan PW |title=Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains. |journal=Biochemistry |volume=45 |issue= 3 |pages= 943-53 |year= 2006 |pmid= 16411770 |doi= 10.1021/bi052202j }}
}}
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{{membrane-protein-stub}}
{{NLM content}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
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