View source for ARVD2

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{{Arrhythmogenic right ventricular dysplasia}}
{{CMG}}

{{SK}} Arrhythmogenic right ventricular dysplasia type 2; arrhythmogenic right ventricular cardiomyopathy 2;  ARVC2

==Overview==
Arrhythmogenic right ventricular dysplasia type 2 is a "concealed form" of ARVD. There is no change in heart size. There are no EKG changes on the resting electrocardiogram, but there may be exercise induced [[polymorphic ventricular tachycardia]]<ref>Rampazzo A, Nava A, Erne P et-al. A new locus for arrhythmogenic right ventricular cardiomyopathy (ARVD2) maps to chromosome 1q42-q43. Hum. Mol. Genet. 1995;4 (11): 2151-4. <a href="http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8589694">Hum. Mol. Genet. (link)</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/8589694">Pubmed citation</a><div class="ref_v2"></div>.</ref>  This variant is associated with premature death.

==Pathophysiology==
Although the heart is normal in size, on pathologic examination, there are large areas of fibro-fatty replacement in the subepicardial layer of the right ventricle. 

There are also abnormalities in calcium hemostasis in the myocytes which may contribute to the occurrence of [[ventricular arrhythmias]].

===Genetics===
This variant ([http://omim.org/entry/600996 600996]) is associated with a mutation in the [[RYR2 gene]] ([http://omim.org/entry/180902 180902]) on chromosome 1q42-q43.

==Epidemiology and Demographics==

==Natural History, Complications, Prognosis==
This ARVD variant is associated with premature death.

==Diagnosis==
===Symptoms===
Exercise induced [[polymorphic VT]] may be present.

===Electrocardiogram===
There are no EKG changes on the resting electrocardiogram, but there may be exercise induced [[polymorphic ventricular tachycardia]].

===Echocardiogram===

===MRI===

==References==
{{Reflist|2}}

[[Category:Cardiology]]
[[Category:Electrophysiology]]