View source for AP1G1

{{Infobox_gene}}
'''AP-1 complex subunit gamma-1''' is a [[protein]] that in humans is encoded by the ''AP1G1'' [[gene]].<ref name="pmid9653655">{{cite journal | vauthors = Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP | title = Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG) | journal = Genomics | volume = 50 | issue = 2 | pages = 275–80 | date = Jun 1998 | pmid = 9653655 | pmc =  | doi = 10.1006/geno.1998.5289 }}</ref><ref name="pmid9733768">{{cite journal | vauthors = Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K | title = Identification and characterization of novel clathrin adaptor-related proteins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24693–700 | date = Sep 1998 | pmid = 9733768 | pmc =  | doi = 10.1074/jbc.273.38.24693 }}</ref>

== Function ==

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: AP1G1 adaptor-related protein complex 1, gamma 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=164| accessdate = }}</ref>

== Interactions ==

AP1G1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[AP1B1]],<ref name = pmid9733768 /><ref name = pmid10535737>{{cite journal | vauthors = Fölsch H, Ohno H, Bonifacino JS, Mellman I | title = A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells | journal = Cell | volume = 99 | issue = 2 | pages = 189–98 | date = Oct 1999 | pmid = 10535737 | doi =  10.1016/s0092-8674(00)81650-5}}</ref><ref name = pmid7593184>{{cite journal | vauthors = Page LJ, Robinson MS | title = Targeting signals and subunit interactions in coated vesicle adaptor complexes | journal = The Journal of Cell Biology | volume = 131 | issue = 3 | pages = 619–30 | date = Nov 1995 | pmid = 7593184 | pmc = 2120623 | doi =  10.1083/jcb.131.3.619}}</ref> 
* [[AP1GBP1]],<ref name = pmid12042876/><ref name = pmid10814529>{{cite journal | vauthors = Takatsu H, Yoshino K, Nakayama K | title = Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin | journal = Biochemical and Biophysical Research Communications | volume = 271 | issue = 3 | pages = 719–25 | date = May 2000 | pmid = 10814529 | doi = 10.1006/bbrc.2000.2700 }}</ref>
* [[AP1M1]],<ref name = pmid10535737/><ref name = pmid7593184/> 
* [[AP1S1]],<ref name = pmid9733768/><ref name = pmid10535737/><ref name = pmid7593184/> 
* [[NECAP2]],<ref name = pmid14665628>{{cite journal | vauthors = Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS | title = Definition of the consensus motif recognized by gamma-adaptin ear domains | journal = The Journal of Biological Chemistry | volume = 279 | issue = 9 | pages = 8018–28 | date = Feb 2004 | pmid = 14665628 | doi = 10.1074/jbc.M311873200 }}</ref> 
* [[RABEP1]],<ref name = pmid12042876>{{cite journal | vauthors = Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S | title = Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain | journal = Nature Structural Biology | volume = 9 | issue = 7 | pages = 527–31 | date = Jul 2002 | pmid = 12042876 | doi = 10.1038/nsb808}}</ref><ref name = pmid12505986>{{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = The EMBO Journal | volume = 22 | issue = 1 | pages = 78–88 | date = Jan 2003 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}</ref>  and
* [[Synaptophysin]].<ref name = pmid12498786>{{cite journal | vauthors = Horikawa HP, Kneussel M, El Far O, Betz H | title = Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin | journal = Molecular and Cellular Neurosciences | volume = 21 | issue = 3 | pages = 454–62 | date = Nov 2002 | pmid = 12498786 | doi =  10.1006/mcne.2002.1191}}</ref> 
{{Div col end}}

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi =  }}
* {{cite journal | vauthors = Page LJ, Sowerby PJ, Lui WW, Robinson MS | title = Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 993–1004 | date = Sep 1999 | pmid = 10477754 | pmc = 2169493 | doi = 10.1083/jcb.146.5.993 }}
* {{cite journal | vauthors = Fölsch H, Ohno H, Bonifacino JS, Mellman I | title = A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells | journal = Cell | volume = 99 | issue = 2 | pages = 189–98 | date = Oct 1999 | pmid = 10535737 | doi = 10.1016/S0092-8674(00)81650-5 }}
* {{cite journal | vauthors = Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS | title = A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome | journal = The Journal of Cell Biology | volume = 149 | issue = 1 | pages = 67–80 | date = Apr 2000 | pmid = 10747088 | pmc = 2175106 | doi = 10.1083/jcb.149.1.67 }}
* {{cite journal | vauthors = Takatsu H, Yoshino K, Nakayama K | title = Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin | journal = Biochemical and Biophysical Research Communications | volume = 271 | issue = 3 | pages = 719–25 | date = May 2000 | pmid = 10814529 | doi = 10.1006/bbrc.2000.2700 }}
* {{cite journal | vauthors = Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K, Hirokawa N | title = A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex | journal = Cell | volume = 103 | issue = 4 | pages = 569–81 | date = Nov 2000 | pmid = 11106728 | doi = 10.1016/S0092-8674(00)00161-6 }}
* {{cite journal | vauthors = Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M | title = The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] | journal = Journal of Virology | volume = 75 | issue = 6 | pages = 2982–92 | date = Mar 2001 | pmid = 11222723 | pmc = 115924 | doi = 10.1128/JVI.75.6.2982-2992.2001 }}
* {{cite journal | vauthors = Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G | title = PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2191–201 | date = May 2001 | pmid = 11331585 | pmc = 125242 | doi = 10.1093/emboj/20.9.2191 }}
* {{cite journal | vauthors = Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K | title = Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system | journal = Biochemical and Biophysical Research Communications | volume = 284 | issue = 4 | pages = 1083–9 | date = Jun 2001 | pmid = 11409905 | doi = 10.1006/bbrc.2001.5081 }}
* {{cite journal | vauthors = Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, Weiss A, Melamed-Book N, Lebendiker M, Altschuler Y, Aroeti B | title = Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 33 | pages = 31340–8 | date = Aug 2001 | pmid = 11418592 | doi = 10.1074/jbc.M101054200 }}
* {{cite journal | vauthors = Doray B, Kornfeld S | title = Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly | journal = Molecular Biology of the Cell | volume = 12 | issue = 7 | pages = 1925–35 | date = Jul 2001 | pmid = 11451993 | pmc = 55640 | doi = 10.1091/mbc.12.7.1925 }}
* {{cite journal | vauthors = Shiba Y, Takatsu H, Shin HW, Nakayama K | title = Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain | journal = Journal of Biochemistry | volume = 131 | issue = 3 | pages = 327–36 | date = Mar 2002 | pmid = 11872161 | doi = 10.1093/oxfordjournals.jbchem.a003107 }}
* {{cite journal | vauthors = Austin C, Boehm M, Tooze SA | title = Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3 | journal = Biochemistry | volume = 41 | issue = 14 | pages = 4669–77 | date = Apr 2002 | pmid = 11926829 | doi = 10.1021/bi016064j }}
* {{cite journal | vauthors = Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M | title = Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25400–7 | date = Jul 2002 | pmid = 11950833 | doi = 10.1074/jbc.M110793200 }}
* {{cite journal | vauthors = Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S | title = Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain | journal = Nature Structural Biology | volume = 9 | issue = 7 | pages = 527–31 | date = Jul 2002 | pmid = 12042876 | doi = 10.1038/nsb808 }}
* {{cite journal | vauthors = Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ | title = Clint: a novel clathrin-binding ENTH-domain protein at the Golgi | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4060–73 | date = Nov 2002 | pmid = 12429846 | pmc = 133614 | doi = 10.1091/mbc.E02-03-0171 }}
{{refend}}

==External links==
* {{UCSC gene info|AP1G1}}
{{PDB Gallery|geneid=164}}
[[Category:Proteins]]