View source for ATP1A4

{{Infobox_gene}}
'''Sodium/potassium-transporting ATPase subunit alpha-4''' is an [[enzyme]] that in humans is encoded by the ''ATP1A4'' [[gene]].<ref name="pmid1981991">{{cite journal | vauthors = Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC | title = A detailed multipoint gene map of chromosome 1q | journal = Genomics | volume = 8 | issue = 1 | pages = 13–21 |date=May 1991 | pmid = 1981991 | pmc =  | doi =10.1016/0888-7543(90)90220-O  }}</ref><ref name="pmid3035563">{{cite journal | vauthors = Shull MM, Lingrel JB | title = Multiple genes encode the human Na+,K+-ATPase catalytic subunit | journal = Proc Natl Acad Sci U S A | volume = 84 | issue = 12 | pages = 4039–43 |date=Jul 1987 | pmid = 3035563 | pmc = 305017 | doi =10.1073/pnas.84.12.4039  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref>

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{{PBB Summary
| section_title = 
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-[[Co-transport|coupled transport]] of a variety of organic and inorganic molecules, and for [[electrical excitability]] of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
}}

==References==
{{reflist}}

==External links==
* {{UCSC gene info|ATP1A1}}
* {{UCSC gene info|ATP1A4}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | vauthors=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue=  |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=10.1016/S0079-6603(08)60708-4  | series=Progress in Nucleic Acid Research and Molecular Biology  | isbn=978-0-12-540038-1  }}
*{{cite journal  | vauthors=Sverdlov ED, Broude NE, Sverdlov VE |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=10.1016/0014-5793(87)80366-6  |display-authors=etal}}
*{{cite journal  | vauthors=Sverdlov ED, Monastyrskaya GS, Broude NE |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=10.1016/0014-5793(87)80677-4  |display-authors=etal}}
*{{cite journal  | vauthors=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952–6 |year= 1995 |pmid= 7809153 |doi=10.1073/pnas.91.26.12952  | pmc=45558  }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39–44 |year= 1999 |pmid= 10227850 |doi=10.1007/PL00005899  }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693–9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc.M002323200 }}
*{{cite journal  | vauthors=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348–56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002 }}
*{{cite journal  | vauthors=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4 |journal=Gene |volume=292 |issue= 1–2 |pages= 151–66 |year= 2002 |pmid= 12119109 |doi=10.1016/S0378-1119(02)00647-9  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Lingrel J, Moseley A, Dostanic I |title=Functional roles of the alpha isoforms of the Na, K-ATPase |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue=  |pages= 354–9 |year= 2003 |pmid= 12763850 |doi=10.1111/j.1749-6632.2003.tb07214.x  |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Hlivko JT, Chakraborty S, Hlivko TJ |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101–15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383 |display-authors=etal}}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | vauthors=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435–47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518 }}
}}
{{refend}}

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{{ATPases}}


{{gene-1-stub}}