View source for Aggressive NK-cell leukemia laboratory findings

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{{Aggressive NK-cell leukemia}}
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==Laboratory Findings==
Leukemic cells are invariably present in samples of peripheral [[blood]] to a variable extent. [[Pancytopenia]] ([[anemia]], [[neutropenia]], [[thrombocytopenia]]) is commonly seen as well.

==Morphology==

===Peripheral blood===
The leukemic cells have a diameter mildly greater than a [[large granular lymphocyte]] (LGL) and have azurophilic granules and nucleoli of varying prominence. Nuclei may be irregular and hyperchromatic.

===Bone marrow===
Bone marrow involvement runs the spectrum between an inconspicuous infiltrate to extensive marrow replacement by leukemic cells. Reactive [[histiocytes]] displaying [[hemophagocytosis]] can been seen interspersed in the [[neoplastic]] infiltrate.

===Other organs===
Leukemic involvement of organs is typically destructive on tissue sections with necrosis and possibly angioinvasion, and the monotonous infiltrate may be diffuse or patchy.



==References==

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[[Category:Needs content]]
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Hematology]]