View source for Amidrine

'''Amidrine''', '''Duradrin''' or '''Midrin''', is a combination of [[Acetaminophen]], [[Dichloralphenazone]], and [[Isometheptene]] used mostly to treat [[headache]]s. 

==Description==
Acetaminophen (paracetamol) is a common over-the-counter pain reliever and [[fever]] reducer.

Dichloralphenazone is a mild [[sedative]] owing primarily to its hydrolysis product, [[Chloral hydrate|chloral hydrate]].  Chloral hydrate, a schedule C-IV controlled substance, is a sedative/hypnotic drug that acts on the central nervous system to produce relaxation and decrease emotional stimuli that influence the perception of pain associated with headache.

Isometheptene is a [[vasoconstrictor]], a drug that causes constriction (narrowing) of cerebral blood vessels. 

The pathophysiology of vascular headaches, especially [[migraine]], is thought to be related to dilation of these cerebral blood vessels, so drugs that act to constrict them are used in the treatment of these problems.

==Common Application==

This drug is commonly used in the treatment of [[Migraine]] headaches and is currently available in the United States and United Kingdom by prescription only.

{{Pharma-stub}}
[[Category:Antimigraine drugs]]