View source for Auer rod

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'''Auer rods''' can be seen in the leukemic blasts of [[Acute Myeloid Leukemia]].  Auer rods are clumps of [[azurophil]]ic granular material that form elongated needles seen in the [[cytoplasm]] of leukemic blasts.  They are composed of fused [[lysosomes]] and contain [[peroxidase]], [[lysosomal]] enzymes, and large crystalline inclusions.

== Diagnosis == 
Auer rods are classically seen in myeloid blasts of M1, M2, M3, and M4 [[Acute_myelogenous_leukemia#French-American-British_classification|acute leukemia]]s.

They are also used to distinguish the pre-leukemia Myelodysplastic Syndromes: Refractory Anemia with Excess Blasts 2 (which has Auer rods) from RAEB 1 (which does not).

===Pathology===

<div align="left">
<gallery heights="175" widths="175">
Image:auer rods.PNG|Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts
Image:AML.jpg|AML - Auer Rods, DIC
Image:AML (with Auer Rods).jpg|AML with Auer Rods
</gallery>
</div>

==Eponym==
These cytoplasmic inclusions were named by [[John Auer]], an American physiologist (1875-1948).<ref>Auer J. ''Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia.'' Am J Med Sci 1906;131:1002-1015.</ref>

==Reference==
<references/>

==External links==
* [http://www.healthsystem.virginia.edu/microscopichematology Overview] at University of Virginia
* [http://www.nlm.nih.gov/medlineplus/ency/imagepages/1441.htm Image] at NIH/[[MedlinePlus]]
* [http://www.wadsworth.org/chemheme/heme/glass/slide_036_myeloauer.htm Slides] at wadsworth.org
* [http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME020.html Image] at [[University of Utah]]



[[Category:Hematology]]
[[Category:Histopathology]]
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