View source for Autonomously replicating sequences

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An '''autonomously replicating sequence''' (ARS) contains the [[origin of replication]] in the [[yeast]] [[genome]]. It contains four regions (A, B1, B2, and B3), named in order of their effect on [[plasmid]] stability; when these regions are mutated, replication does not initiate.

Element A is highly conserved, consisting of the consensus sequence:

 5'- T/A T T T A Y R T T T T/A -3'
(where ''Y'' is either [[pyrimidine]] and ''R'' is either [[purine]]). When this element is mutated, the ARS loses all activity.
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[[it:ARS (biologia)]]
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