View source for BZIP domain

{{lowercase|title=bZIP domain}}
:''This article is about the protein domain. For the compression algorithm, see [[Bzip2]].''
{{Pfam_box
| Symbol = bZIP_1
| Name = bZIP transcription factor
| image =CREB.png
| width =220
| caption =CREB (top) is a [[transcription factor]] capable of binding [[DNA]] via the bZIP domain (bottom) and regulating [[gene expression]].
| Pfam= PF00170
| InterPro= IPR011616
| SMART=
| PROSITE=PDOC00036
| SCOP = 1ysa
| TCDB =
| OPM family=
| OPM protein=
| PDB=
{{PDB3|1dh3}}A:285-339   {{PDB3|1t2k}}D:336-395   {{PDB3|1s9k}}E:257-308
{{PDB3|1jun}}B:276-313   {{PDB3|1jnm}}A:254-313   {{PDB3|1a02}}J:257-308
{{PDB3|1swi}}B:249-278   {{PDB3|1ce9}}A:251-279   {{PDB3|1uo0}}A:249-279
{{PDB3|1rb5}}B:249-279   {{PDB3|1unw}}B:249-279   {{PDB3|1vzl}}B:249-279
{{PDB3|1unt}}A:249-279   {{PDB3|1zim}}C:249-279   {{PDB3|1w5j}}D:249-279
{{PDB3|1zij}}A:249-279   {{PDB3|1rb6}}A:249-279   {{PDB3|2zta}}A:249-279
{{PDB3|1uo5}}B:249-279   {{PDB3|1rb1}}C:249-279   {{PDB3|1gcl}}C:249-279
{{PDB3|1w5g}}B:249-279   {{PDB3|1w5i}}A:249-279   {{PDB3|1uo1}}A:249-279
{{PDB3|1unu}}B:249-279   {{PDB3|1gcm}}A:249-279   {{PDB3|1rb4}}C:249-279
{{PDB3|1uo2}}B:249-279   {{PDB3|1ysa}}D:226-279   {{PDB3|1unz}}B:249-279
{{PDB3|1w5k}}D:249-279   {{PDB3|1ij1}}A:249-279   {{PDB3|1zta}} :247-279
{{PDB3|1ij0}}A:249-279   {{PDB3|1uo3}}A:249-279   {{PDB3|1w5h}}A:249-279
{{PDB3|1ij2}}A:249-279   {{PDB3|1dgc}}A:227-279   {{PDB3|1w5l}}B:249-279
{{PDB3|1uny}}A:249-279   {{PDB3|2b1f}}B:251-279   {{PDB3|2bni}}B:249-279
{{PDB3|1zil}}A:249-278   {{PDB3|1zii}}A:249-279   {{PDB3|1unv}}B:249-279
{{PDB3|1zik}}B:249-278   {{PDB3|1unx}}A:249-279   {{PDB3|1ij3}}B:249-279
{{PDB3|1uo4}}A:249-279   {{PDB3|1kql}}B:255-279   {{PDB3|2dgc}}A:229-277
{{PDB3|1piq}}A:249-279   {{PDB3|2b22}}A:251-279   {{PDB3|1lvx}}A:265-294
{{PDB3|1gd2}}H:74-137    {{PDB3|1ci6}}A:280-339
}}

{{CMG}}



The '''Basic Leucine Zipper Domain''' ('''bZIP domain''') is found in many [[DNA]] binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the [[leucine zipper]] that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as [[arginine]] and [[lysine]].

==bZIP domain containing proteins==
*AP-1 [[fos]]/[[Jun (protein)|jun]] heterodimer that forms a [[transcription factor]]
*[[Jun-B]] transcription factor
*[[CREB]] cAMP response element transcription factor
*OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize  (''Zea Mays'') kernels

==Human proteins containing this domain ==
[[ATF1]];      [[ATF2]];      [[ATF4]];      [[ATF5]];      [[ATF6]];      [[ATF7]];      [[BACH1]];     [[BACH2]];
[[BATF]];      [[BATF2]];     [[CREB1]];     [[CREB3]];     [[CREB3L1]];   [[CREB3L2]];   [[CREB3L3]];   [[CREB3L4]];
[[CREB5]];     [[CREBL1]];    [[CREM]];      [[E4BP4]];     [[FOSL1]];     [[FOSL2]];     [[JUN]];       [[JUNB]];      [[JUND]];
[[NFE2]];      [[NFE2L2]];    [[NFE2L3]];    [[SNFT]];      [[CREM]]

==External links==
*[http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=BRLZ bZIP domain entry in the SMART database]

{{Protein domains}}
{{Transcription factors}}
[[Category:Protein domains]]
[[Category:Protein structure]]
[[Category:Proteins]]

[[de:BZIP-Domäne]]

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