View source for Biliary cystadenoma and cystadenocarcinoma natural history, complications and prognosis

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{{Biliary cystadenoma and cystadenocarcinoma}}
{{CMG}};{{AE}} {{PSK}}
==Overview==
Common complication of biliary cystadenoma include neoplastic transformation to biliary cystadenocarcinoma. Biliary cystadenoma with mesenchymal stroma is associated with most favorable [[prognosis]].<ref name="Ahanatha PillaiVelayutham2012">{{cite journal|last1=Ahanatha Pillai|first1=Sastha|last2=Velayutham|first2=Vimalraj|last3=Perumal|first3=Senthilkumar|last4=Ulagendra Perumal|first4=Srinivasan|last5=Lakshmanan|first5=Anand|last6=Ramaswami|first6=Sukumar|last7=Ramasamy|first7=Ravi|last8=Sathyanesan|first8=Jeswanth|last9=Palaniappan|first9=Ravichandran|last10=Rajagopal|first10=Surendran|title=Biliary Cystadenomas: A Case for Complete Resection|journal=HPB Surgery|volume=2012|year=2012|pages=1–6|issn=0894-8569|doi=10.1155/2012/501705}}</ref>

==Complications==
*In fact, even if the cystadenoma is a [[benign neoplasm]], it has a high rate of recurrence and a potential for neoplastic transformation.
*Malignant transformation rate can be as high as 30%.<ref name="RamacciatoNigri2006">{{cite journal|last1=Ramacciato|first1=Giovanni|last2=Nigri|first2=Giuseppe R|last3=D'Angelo|first3=Francesco|last4=Aurello|first4=Paolo|last5=Bellagamba|first5=Riccardo|last6=Colarossi|first6=Cristina|last7=Pilozzi|first7=Emanuela|last8=Del Gaudio|first8=Massimo|journal=World Journal of Surgical Oncology|volume=4|issue=1|year=2006|pages=76|issn=14777819|doi=10.1186/1477-7819-4-76}}</ref>

==Prognosis==
Although biliary cystadenomas are benign tumors, they may recur after excision and have potential to develop into biliary cystadenocarcinomas.<ref name=radio1>Biliary cystadenoma.Dr Yuranga Weerakkody and Radswiki et al.Radiopaedia.org 2015. http://radiopaedia.org/articles/biliary-cystadenoma</ref>
===Biliary cystadenoma===
*The prognosis of completely removed billiary cystadenomas is excellent, recurrence is rare.<ref name=bkjjk>{{Citation |last=Kuberan |first=K.|last=Chandrasekar |first=G. |year=2015 |title=Biliary Cystadenoma of Liver. |publisher=Stanley Medical Journal |publication-place=Chennai |page=37-42 |url=http://smj.org.in/article/pdf/83.pdf |accessdate=December 10, 2015 }}</ref>
*Cystadenomas with mesenchymal stroma are considered [[premalignant]] with a good prognosis while those without are known to transform to [[malignancy]] more often with a poor prognosis.<ref name="Ahanatha PillaiVelayutham2012">{{cite journal|last1=Ahanatha Pillai|first1=Sastha|last2=Velayutham|first2=Vimalraj|last3=Perumal|first3=Senthilkumar|last4=Ulagendra Perumal|first4=Srinivasan|last5=Lakshmanan|first5=Anand|last6=Ramaswami|first6=Sukumar|last7=Ramasamy|first7=Ravi|last8=Sathyanesan|first8=Jeswanth|last9=Palaniappan|first9=Ravichandran|last10=Rajagopal|first10=Surendran|title=Biliary Cystadenomas: A Case for Complete Resection|journal=HPB Surgery|volume=2012|year=2012|pages=1–6|issn=0894-8569|doi=10.1155/2012/501705}}</ref>

===Biliary cystadenocarcinoma===
*When treated with radical excision biliary cystadenocarcinomas have good prognosis, particularly those with mesenchymal stroma, unless the tumor invades the adjacent liver tissue or neighboring organs, or metastases are present.<ref name=bkjjk>{{Citation |last=Kuberan |first=K.|last=Chandrasekar |first=G. |year=2015 |title=Biliary Cystadenoma of Liver. |publisher=Stanley Medical Journal |publication-place=Chennai |page=37-42 |url=http://smj.org.in/article/pdf/83.pdf |accessdate=December 10, 2015 }}</ref>
*Biliary cystadenocarcinomas in men which are not associated with mesenchymal stroma have worse prognosis, even after complete excision.<ref name=bkjjk>{{Citation |last=Kuberan |first=K.|last=Chandrasekar |first=G. |year=2015 |title=Biliary Cystadenoma of Liver. |publisher=Stanley Medical Journal |publication-place=Chennai |page=37-42 |url=http://smj.org.in/article/pdf/83.pdf |accessdate=December 10, 2015 }}</ref>

==References==
{{Reflist|2}}
[[Category:Disease]]
[[Category:Gastroenterology]]
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