View source for C8 complex

[[File:3OJY.png|thumb|High Resolution Crystal Structure of Human Complement Component 8]]

{{protein
| Name = complement component 8, alpha polypeptide
| caption = 
| image = 
| width = 
| HGNCid = 1352
| Symbol = C8A
| AltSymbols = 
| EntrezGene = 731
| OMIM = 120950
| RefSeq = NM_000562
| UniProt = P07357
| PDB = 
| ECnumber = 
| Chromosome = 1
| Arm = p
| Band = 36.2
| LocusSupplementaryData = -22.1
}}
{{protein
| Name = complement component 8, beta polypeptide
| caption = 
| image = 
| width = 
| HGNCid = 1353
| Symbol = C8B
| AltSymbols = 
| EntrezGene = 732
| OMIM = 1209660
| RefSeq = NM_000066
| UniProt = P073o58
| PDB = 
| ECnumber = 
| Chromosome = 1
| Arm = p
| Band = 36.2
| LocusSupplementaryData = -22.1
}}
{{protein
| Name = complement component 8, gamma polypeptide
| caption = 
| image = 
| width = 
| HGNCid = 1354
| Symbol = C8G
| AltSymbols = 
| EntrezGene = 733
| OMIM = 120930
| RefSeq = NM_000606
| UniProt = P07360
| PDB = 
| ECnumber = 
| Chromosome = 9
| Arm = q
| Band = 34.3
| LocusSupplementaryData = 
}}
'''Complement component 8''' is a [[protein]] involved in the [[complement system]]. It is part of the [[complement membrane attack complex|membrane attack complex (MAC)]].

A [[Heredity|hereditary]] deficiency of C8 can result in increased [[Susceptible individual|susceptibility]] to [[Neisseria]] infections, such as [[meningitis]] and [[gonorrhea]].

[[Image:Formowanie MAC.svg|thumb|400px|top|Membrane attack complex. Some labels are in Polish.]]

==Structure==
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the [[Gene|genes]] ''C8A'', ''C8B'' and ''C8G'' respectively.

==References==
1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25.   Figure created in Pymol

==External links==
* {{MeshName|Complement+C8}}

{{Complement system}}

The crystal structure is now in the PDB, PDB ID 3OJY.

[[Category:Complement system]]


{{gene-9-stub}}