View source for CCL15

{{infobox protein
| Name = chemokine (C-C motif) ligand 15
| caption = 
| image = 
| width = 
| HGNCid = 10613
| Symbol = CCL15
| AltSymbols = SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
| EntrezGene = 6359
| OMIM = 601393
| RefSeq = NM_032965
| UniProt = Q16663
| PDB = 2HCC
| ECnumber = 
| Chromosome = 17
| Arm = q
| Band = 11.2
| LocusSupplementaryData = 
}}

'''Chemokine (C-C motif) ligand 15''' (CCL15) is a small [[cytokine]] belonging to the CC [[chemokine]] family that is also known as leukotactin-1, MIP5 and HCC-2.  CCL15 is expressed in [[liver]], [[small intestine]], [[Colon (anatomy)|colon]], and in certain [[leukocyte]]s and [[macrophage]]s of the [[lung]].<ref>Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998. 
</ref> It is [[chemotactic]] for [[neutrophil]]s, [[monocyte]]s, and [[lymphocyte]]s and elicits its effects by binding to cell surface [[chemokine receptor]]s like [[CC chemokine receptors#CCR1|CCR1]] and [[CC chemokine receptors#CCR3|CCR3]].<ref>Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.</ref><ref>Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.</ref>  The human CCL15 [[gene]] spans four [[exon]]s and is located in a head-to-tail orientation on [[chromosome 17]] with the gene of another CC chemokine known as [[CCL14]].<ref>Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.</ref>

==References==
<references/>

==External links==
* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL15#disorders CCL15 GeneCard]

{{Chemokines}}
{{Chemokine receptor modulators}}

[[Category:Cytokines]]


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