View source for Cefsulodin

<div style="float: right;">
[[File:Cefsulodin.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div>
__NOTOC__
{{SI}}
{{CMG}}
==Overview==
'''Cefsulodin''' is a third-generation [[cephalosporin]] antibiotic with specific activity against ''[[Pseudomonas aeruginosa]]''. It has no significant activity against other Gram-negative bacteria and very limited activity against Gram-positive bacteria and anaerobic bacteria. Cefsulodin was first synthesized and patented by the [[Takeda Pharmaceutical Company]] in 1977. In 2002, Takeda stopped production of cefsulodin. Many years of low-stability cefsulodin production has led to a widespread reduction of laboratory and research uses. Current attempts (i.e. [[IDEXX Laboratories]]) of increasing purity and stability of cefsulodin center around recrystallization. Typically, the process entails: Cefsulodin is dissolved in an organic solvent, sodium ions, water, or any mixture thereof, then subsequently recrystallized through separation of the unwanted fraction. Recently, [[TOKU-E]] has found the main cause of cefsulodin instability stems from one key impurity in [[7-ACA|7-aminocephalosporanic acid]], a raw material used in the synthesis of cefsulodin. To produce high-purity, high-stability cefsulodin, TOKU-E uses industrial HPLC to remove significant quantities of this impurity in 7-ACA and thus produces ultrapure, ultrastable, and ultrapotent cefsulodin.<ref name="racgp">[http://www.toku-e.com/Upload/Products/Article/20110323002554.pdf], TOKU-E Technical Application Sheet.</ref>
== General use ==
Cefuslodin is most commonly used in cefsulodin-irgasan-novobiocin agar to select for ''Yersinia'' microorganisms.<ref>{{cite web|title=BAM Media M35: Cefsulodin-Irgasan Novobiocin Agar or Yersinia Selective Agar|url=http://www.fda.gov/Food/ScienceResearch/LaboratoryMethods/BacteriologicalAnalyticalManualBAM/ucm064575.htm|accessdate=2 September 2012}}</ref> This agar is most often used in water and beverage testing.
== Susceptibility data ==
The following represents MIC susceptibility data for various ''P. aeruginosa'' strains.
* ''Pseudomonas aeruginosa'' PA13 (resistant strain): 32 μg/ml
* ''Pseudomonas aeruginosa'' (wild-type, susceptible): 4 - 8 μg/ml
<ref>http://antibiotics.toku-e.com/antimicrobial_474.html</ref>

==References==
{{Reflist|2}}

{{CephalosporinAntiBiotics}}
[[Category:Cephalosporin antibiotics]]
[[Category:Drug]]