View source for Chemical modification



==Overview==
In [[biochemistry]], '''chemical modification''' is the technique of chemically reacting a [[protein]] or [[nucleic acid]] with chemical reagents.  Chemical modification can have several goals, such as

* to identify which parts of the molecule are exposed to solvent ("foot printing");
* to determine which residues are important for a particular phenotype, e.g., which residues are important for an enzymatic activity;
* to introduce new groups into a macromolecule; and 
* to crosslink macromolecules intra- and intermolecularly.

==Chemical modification of protein side chains==


==Chemical modification of nucleic acids==


{{Protein structure determination}}


[[Category:Protein structure]]
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