View source for Collagenases

{{protein | Name = [[MMP1|matrix metallopeptidase 1 (interstitial collagenase)]] | caption = | image = | width = | HGNCid = 7155 | Symbol = [[MMP1]] | AltSymbols = | EntrezGene = 4312 | OMIM = 120353 | RefSeq = NM_002421 | UniProt = P03956 | PDB = | ECnumber = 3.4.24.7 | Chromosome = 11 | Arm = q | Band = 21 | LocusSupplementaryData = -q22 }}
{{protein | Name = [[MMP8|matrix metallopeptidase 8 (neutrophil collagenase)]] | caption = | image = | width = | HGNCid = 7175 | Symbol = [[MMP8]] | AltSymbols = | EntrezGene = 4317 | OMIM = 120355 | RefSeq = NM_002424 | UniProt = P22894 | PDB = | ECnumber = 3.4.24.34 | Chromosome = 11 | Arm = q | Band = 21 | LocusSupplementaryData = -q22 }}


'''Collagenases''' are [[enzymes]] that break the [[peptide bonds]] in [[collagen]]. 

They assist in destroying extracellular structures in pathogenesis of bacteria such as ''[[Clostridium]]''. They are an [[exotoxin]] (a virulence factor) and help to facilitate the spread of [[gas gangrene]]. They normally target the connective tissue in muscle cells and other body organs.<ref>{{cite book |author=Gerard J. Tortora, Berdell R. Funke, Cristine L. Case |title=Microbiology: an introduction |publisher=Pearson Benjamin Cummings |year=2007 |isbn=03-213-960-30}}</ref>

Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.

Collagenase production can be induced during an immune response, by [[cytokine]]s which stimulate cells such as [[fibroblasts]] and [[osteoblasts]], and cause indirect tissue damage.{{Fact|date=November 2007}}

SANTYL Ointment, a Healthpoint, Ltd. product, is the only FDA approved product containing Collagenase as its primary ingredient.

They are categorized under [[EC number]] 3.4.24.

==See also==
* [[Matrix metalloproteinase]]
* [[Gas gangrene]]

==References==
{{reflist|2}}

==External links==
* {{MeshName|Collagenases}}

{{Metalloproteinases}}

[[Category:EC 3.4.24]]

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[[fr:Collagénase]]
[[zh:胶原酶]]

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