View source for Corticotropin releasing hormone receptor 1

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Corticotropin releasing hormone receptor 1
 | HGNCid = 2357
 | Symbol = CRHR1
 | AltSymbols =; CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f
 | OMIM = 122561
 | ECnumber =  
 | Homologene = 20920
 | MGIid = 88498
 | GeneAtlas_image1 = PBB_GE_CRHR1_214619_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CRHR1_208593_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_CRHR1_211897_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0015056 |text = corticotrophin-releasing factor receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007567 |text = parturition}} {{GNF_GO|id=GO:0007610 |text = behavior}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1394
    | Hs_Ensembl = ENSG00000120088
    | Hs_RefseqProtein = XP_001128344
    | Hs_RefseqmRNA = XM_001128344
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 41239997
    | Hs_GenLoc_end = 41267911
    | Hs_Uniprot = P34998
    | Mm_EntrezGene = 12921
    | Mm_Ensembl = ENSMUSG00000018634
    | Mm_RefseqmRNA = NM_007762
    | Mm_RefseqProtein = NP_031788
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 103948972
    | Mm_GenLoc_end = 103991608
    | Mm_Uniprot = Q0VGH2
  }}
}}
'''Corticotropin releasing hormone receptor 1''', also known as '''CRHR1''', is a human [[gene]].

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{{PBB_Summary
| section_title = 
| summary_text = The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone (MIM 122560), a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CRHR1 corticotropin releasing hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1394| accessdate = }}</ref>
}}

==See also==
* [[Corticotropin releasing hormone receptor]]
* [[Corticotropin releasing hormone antagonists]]
* [[Antalarmin]]
* [[Pexacerfont]]

==References==
{{reflist|2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Taché Y, Martinez V, Wang L, Million M |title=CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. |journal=Br. J. Pharmacol. |volume=141 |issue= 8 |pages= 1321-30 |year= 2004 |pmid= 15100165 |doi= 10.1038/sj.bjp.0705760 }}
*{{cite journal  | author=McLean M, Bisits A, Davies J, ''et al.'' |title=A placental clock controlling the length of human pregnancy. |journal=Nat. Med. |volume=1 |issue= 5 |pages= 460-3 |year= 1995 |pmid= 7585095 |doi=  }}
*{{cite journal  | author=Polymeropoulos MH, Torres R, Yanovski JA, ''et al.'' |title=The human corticotropin-releasing factor receptor (CRHR) gene maps to chromosome 17q12-q22. |journal=Genomics |volume=28 |issue= 1 |pages= 123-4 |year= 1995 |pmid= 7590738 |doi= 10.1006/geno.1995.1118 }}
*{{cite journal  | author=Chen R, Lewis KA, Perrin MH, Vale WW |title=Expression cloning of a human corticotropin-releasing-factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8967-71 |year= 1993 |pmid= 7692441 |doi=  }}
*{{cite journal  | author=Ross PC, Kostas CM, Ramabhadran TV |title=A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1836-42 |year= 1995 |pmid= 7811272 |doi= 10.1006/bbrc.1994.2884 }}
*{{cite journal  | author=Opdenakker G, Fiten P, Nys G, ''et al.'' |title=The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12. |journal=Genomics |volume=21 |issue= 2 |pages= 403-8 |year= 1994 |pmid= 7916328 |doi= 10.1006/geno.1994.1283 }}
*{{cite journal  | author=Vita N, Laurent P, Lefort S, ''et al.'' |title=Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. |journal=FEBS Lett. |volume=335 |issue= 1 |pages= 1-5 |year= 1993 |pmid= 8243652 |doi=  }}
*{{cite journal  | author=Donaldson CJ, Sutton SW, Perrin MH, ''et al.'' |title=Cloning and characterization of human urocortin. |journal=Endocrinology |volume=137 |issue= 5 |pages= 2167-70 |year= 1996 |pmid= 8612563 |doi=  }}
*{{cite journal  | author=Liaw CW, Grigoriadis DE, Lovenberg TW, ''et al.'' |title=Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach. |journal=Mol. Endocrinol. |volume=11 |issue= 7 |pages= 980-5 |year= 1997 |pmid= 9178757 |doi=  }}
*{{cite journal  | author=Asakura H, Zwain IH, Yen SS |title=Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 8 |pages= 2720-5 |year= 1997 |pmid= 9253360 |doi=  }}
*{{cite journal  | author=Gottowik J, Goetschy V, Henriot S, ''et al.'' |title=Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin. |journal=Neuropharmacology |volume=36 |issue= 10 |pages= 1439-46 |year= 1998 |pmid= 9423932 |doi=  }}
*{{cite journal  | author=Grammatopoulos D, Dai Y, Chen J, ''et al.'' |title=Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 7 |pages= 2539-44 |year= 1998 |pmid= 9661640 |doi=  }}
*{{cite journal  | author=Sakai K, Yamada M, Horiba N, ''et al.'' |title=The genomic organization of the human corticotropin-releasing factor type-1 receptor. |journal=Gene |volume=219 |issue= 1-2 |pages= 125-30 |year= 1998 |pmid= 9757017 |doi=  }}
*{{cite journal  | author=Grammatopoulos DK, Dai Y, Randeva HS, ''et al.'' |title=A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2189-202 |year= 2000 |pmid= 10598591 |doi=  }}
*{{cite journal  | author=Lewis K, Li C, Perrin MH, ''et al.'' |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570-5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198 }}
*{{cite journal  | author=Perrin MH, Fischer WH, Kunitake KS, ''et al.'' |title=Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31528-34 |year= 2001 |pmid= 11425856 |doi= 10.1074/jbc.M101838200 }}
*{{cite journal  | author=Pisarchik A, Slominski AT |title=Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. |journal=FASEB J. |volume=15 |issue= 14 |pages= 2754-6 |year= 2002 |pmid= 11606483 |doi= 10.1096/fj.01-0487fje }}
*{{cite journal  | author=Graziani G, Tentori L, Portarena I, ''et al.'' |title=CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway. |journal=Endocrinology |volume=143 |issue= 3 |pages= 807-13 |year= 2002 |pmid= 11861501 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=King JS, Bishop GA |title=The distribution and cellular localization of CRF-R1 in the vermis of the postnatal mouse cerebellum. |journal=Exp. Neurol. |volume=178 |issue= 2 |pages= 175-85 |year= 2003 |pmid= 12504877 |doi=  }}
}}
{{refend}}

==External links==
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1321 IUPHAR GPCR Database - Corticotropin-releasing factor receptors]
* {{MeshName|Corticotropin-releasing+hormone+receptors}}

{{G protein-coupled receptors}}
{{membrane-protein-stub}}
{{NLM content}}
[[Category:G protein coupled receptors]]
[[Category:Corticotropin-releasing hormone]]