View source for Cytochrome p450 family 19 subfamily a member 1

{{Infobox_gene}}

'''Cytochrome P450 family 19 subfamily A member 1''' is a [[protein]] that in humans is encoded by the CYP19A1 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: Cytochrome P450 family 19 subfamily A member 1
| url = https://www.ncbi.nlm.nih.gov/gene/1588
| accessdate = 2018-06-07
}}</ref>

==Function==

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

== References ==

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== Further reading ==

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*{{cite journal |vauthors=Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP |title=A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory |journal=Clin. Genet. |volume=58 |issue=5 |pages=375–85 |date=November 2000 |pmid=11140838 |doi= |url=}}
*{{cite journal |vauthors=Baxter SW, Choong DY, Eccles DM, Campbell IG |title=Polymorphic variation in CYP19 and the risk of breast cancer |journal=Carcinogenesis |volume=22 |issue=2 |pages=347–9 |date=February 2001 |pmid=11181459 |doi= |url=}}
*{{cite journal |vauthors=Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev MY, Sokolov EP, Togo A, Hanson KP, Poroshina TE, Vasiljev DA, Kovalevskij AY, Gamajunova VB |title=CYP19 gene polymorphism in endometrial cancer patients |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue=2 |pages=135–8 |date=February 2001 |pmid=11216915 |doi= |url=}}
*{{cite journal |vauthors=Tucci S, Futterweit W, Concepcion ES, Greenberg DA, Villanueva R, Davies TF, Tomer Y |title=Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue=1 |pages=446–9 |date=January 2001 |pmid=11232039 |doi=10.1210/jcem.86.1.7274 |url=}}
*{{cite journal |vauthors=Masi L, Becherini L, Gennari L, Amedei A, Colli E, Falchetti A, Farci M, Silvestri S, Gonnelli S, Brandi ML |title=Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue=5 |pages=2263–9 |date=May 2001 |pmid=11344237 |doi=10.1210/jcem.86.5.7450 |url=}}
*{{cite journal |vauthors=Latil AG, Azzouzi R, Cancel GS, Guillaume EC, Cochan-Priollet B, Berthon PL, Cussenot O |title=Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways |journal=Cancer |volume=92 |issue=5 |pages=1130–7 |date=September 2001 |pmid=11571725 |doi= |url=}}
*{{cite journal |vauthors=Modugno F, Weissfeld JL, Trump DL, Zmuda JM, Shea P, Cauley JA, Ferrell RE |title=Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk |journal=Clin. Cancer Res. |volume=7 |issue=10 |pages=3092–6 |date=October 2001 |pmid=11595700 |doi= |url=}}
*{{cite journal |vauthors=Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S |title=Role of aromatase in endometrial disease |journal=J. Steroid Biochem. Mol. Biol. |volume=79 |issue=1-5 |pages=19–25 |date=December 2001 |pmid=11850203 |doi= |url=}}
*{{cite journal |vauthors=Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, Kao YC, Itoh T |title=Modulation of aromatase expression in human breast tissue |journal=J. Steroid Biochem. Mol. Biol. |volume=79 |issue=1-5 |pages=35–40 |date=December 2001 |pmid=11850205 |doi= |url=}}

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